Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 403554..404902 Replicon chromosome
Accession NZ_LR134490
Organism Haemophilus influenzae strain NCTC11873

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag EL230_RS02040 Protein ID WP_048954893.1
Coordinates 403871..404902 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag EL230_RS02035 Protein ID WP_048954894.1
Coordinates 403554..403874 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL230_RS01995 398797..399075 + 279 WP_005658968.1 cell division protein FtsB -
EL230_RS02000 399075..399752 + 678 WP_050847476.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
EL230_RS02005 399749..400225 + 477 WP_050847477.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
EL230_RS09780 400277..400444 - 168 WP_164713688.1 hypothetical protein -
EL230_RS02010 400709..401143 - 435 WP_021034583.1 D-tyrosyl-tRNA(Tyr) deacylase -
EL230_RS02015 401140..401580 - 441 WP_005667635.1 FMN-binding protein MioC -
EL230_RS02020 401677..401895 - 219 WP_005650820.1 cell division protein ZapB -
EL230_RS02025 402057..403058 + 1002 WP_005690169.1 class II fructose-bisphosphatase -
EL230_RS02030 403258..403566 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
EL230_RS02035 403554..403874 + 321 WP_048954894.1 type II toxin-antitoxin system HipA family toxin Antitoxin
EL230_RS02040 403871..404902 + 1032 WP_048954893.1 type II toxin-antitoxin system HipA family toxin Toxin
EL230_RS02045 404986..406644 - 1659 WP_005650826.1 thiol reductant ABC exporter subunit CydC -
EL230_RS02050 406637..408382 - 1746 WP_126513437.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39788.40 Da        Isoelectric Point: 6.4338

>T287947 WP_048954893.1 NZ_LR134490:403871-404902 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKNFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLHEPEL

Download         Length: 1032 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12433.09 Da        Isoelectric Point: 6.2114

>AT287947 WP_048954894.1 NZ_LR134490:403554-403874 [Haemophilus influenzae]
MRNLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References