287943

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4692289..4693043 Replicon chromosome
Accession NZ_LR134485
Organism Citrobacter youngae strain NCTC13709

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL296_RS23185 Protein ID WP_048214029.1
Coordinates 4692289..4692600 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL296_RS23190 Protein ID WP_124021981.1
Coordinates 4692597..4693043 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL296_RS23155 4687956..4688858 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
EL296_RS23160 4688855..4689490 + 636 WP_005121818.1 formate dehydrogenase cytochrome b556 subunit -
EL296_RS23165 4689487..4690416 + 930 WP_061066954.1 formate dehydrogenase accessory protein FdhE -
EL296_RS23170 4690453..4690827 - 375 WP_101741972.1 type II toxin-antitoxin system VapC family toxin -
EL296_RS23175 4690827..4691069 - 243 WP_005121822.1 ribbon-helix-helix domain-containing protein -
EL296_RS23180 4691274..4692203 + 930 WP_124021982.1 alpha/beta hydrolase -
EL296_RS23185 4692289..4692600 + 312 WP_048214029.1 type II toxin-antitoxin system HigB family toxin Toxin
EL296_RS23190 4692597..4693043 + 447 WP_124021981.1 helix-turn-helix domain-containing protein Antitoxin
EL296_RS23195 4693055..4693996 - 942 WP_048214031.1 fatty acid biosynthesis protein FabY -
EL296_RS23200 4694041..4694478 - 438 WP_003028671.1 D-tyrosyl-tRNA(Tyr) deacylase -
EL296_RS23205 4694475..4695347 - 873 WP_124021980.1 virulence factor BrkB family protein -
EL296_RS23210 4695341..4695939 - 599 Protein_4436 glucose-1-phosphatase -
EL296_RS23215 4696045..4696848 - 804 WP_003847907.1 DeoR/GlpR family DNA-binding transcription regulator -
EL296_RS23220 4696882..4697778 - 897 WP_048214034.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12429.40 Da        Isoelectric Point: 9.5341

>T287943 WP_048214029.1 NZ_LR134485:4692289-4692600 [Citrobacter youngae]
VHVISRKPFNEGMLMYPNHGLALSELLNVLEKKTFNHPEEMKQYIPSLDNFKYRNKWWVIDVSGNNLRLIAYIDFRLHKV
FVKHIVLHAEYDKLTEYYRGHKE

Download         Length: 312 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16711.12 Da        Isoelectric Point: 6.9808

>AT287943 WP_124021981.1 NZ_LR134485:4692597-4693043 [Citrobacter youngae]
MRSHRHMDAASAKKIVDTFSCAVKTIPLLGEERNETEYRRALALVEFLVDHDDLENPLFELLSARISEYEKYAPEFRALN
QHLKQIPSGVSVLRTLMDQYGLKATDLANELGSKSNVSNILNGRRALTVSHIKALAERFKLPADAFIE

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References