287940

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4441966..4442636 Replicon chromosome
Accession NZ_LR134485
Organism Citrobacter youngae strain NCTC13709

Toxin (Protein)


Gene name higB Uniprot ID A0A6N6JXY6
Locus tag EL296_RS22005 Protein ID WP_046671374.1
Coordinates 4442334..4442636 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL296_RS22000 Protein ID WP_048213890.1
Coordinates 4441966..4442307 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL296_RS21970 4437587..4438345 + 759 WP_048213884.1 phosphonate C-P lyase system protein PhnK -
EL296_RS21975 4438355..4439035 + 681 WP_124021050.1 phosphonate C-P lyase system protein PhnL -
EL296_RS21980 4439032..4440168 + 1137 WP_124021051.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
EL296_RS21985 4440171..4440725 + 555 WP_124021052.1 ribose 1,5-bisphosphokinase -
EL296_RS21990 4440712..4441146 + 435 WP_124021053.1 aminoalkylphosphonate N-acetyltransferase -
EL296_RS21995 4441155..4441913 + 759 WP_124021054.1 phosphonate metabolism protein PhnP -
EL296_RS22000 4441966..4442307 - 342 WP_048213890.1 HigA family addiction module antidote protein Antitoxin
EL296_RS22005 4442334..4442636 - 303 WP_046671374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL296_RS22010 4442792..4443121 - 330 WP_124021055.1 hypothetical protein -
EL296_RS22015 4443191..4445455 - 2265 WP_124021056.1 hybrid sensor histidine kinase/response regulator -
EL296_RS22025 4445570..4447093 + 1524 WP_124021057.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11819.43 Da        Isoelectric Point: 9.9581

>T287940 WP_046671374.1 NZ_LR134485:c4442636-4442334 [Citrobacter youngae]
MSKSLNIRSFRDTWLEDFFERATSHRKIPADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWVNGKAEDVYLDPHIY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13089.90 Da        Isoelectric Point: 6.4763

>AT287940 WP_048213890.1 NZ_LR134485:c4442307-4441966 [Citrobacter youngae]
MKQATRKPTTVGDILQYEYLEPLELKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRNSESKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N6JXY6

Antitoxin

Source ID Structure

References