Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 840461..841147 Replicon chromosome
Accession NZ_LR134482
Organism Pseudomonas stutzeri strain NCTC10475

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL330_RS03860 Protein ID WP_101275056.1
Coordinates 840461..840814 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W9TFC1
Locus tag EL330_RS03865 Protein ID WP_037038764.1
Coordinates 840818..841147 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL330_RS03820 835678..836334 + 657 WP_126514543.1 hypothetical protein -
EL330_RS03830 836880..837098 + 219 WP_014852368.1 hypothetical protein -
EL330_RS03835 837095..837310 + 216 WP_045666264.1 hypothetical protein -
EL330_RS20940 837303..837692 + 390 WP_172602746.1 hypothetical protein -
EL330_RS03845 837780..838079 + 300 WP_101275058.1 hypothetical protein -
EL330_RS03850 838149..839429 + 1281 WP_101275057.1 hypothetical protein -
EL330_RS03855 839429..840412 + 984 WP_101275415.1 tyrosine-type recombinase/integrase -
EL330_RS03860 840461..840814 + 354 WP_101275056.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL330_RS03865 840818..841147 + 330 WP_037038764.1 XRE family transcriptional regulator Antitoxin
EL330_RS03875 841749..842054 - 306 WP_101275055.1 hypothetical protein -
EL330_RS03880 842236..845088 - 2853 WP_101275054.1 FAD-binding oxidoreductase -
EL330_RS03885 845085..845756 - 672 WP_038663056.1 lactate utilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13520.87 Da        Isoelectric Point: 4.6682

>T287928 WP_101275056.1 NZ_LR134482:840461-840814 [Pseudomonas stutzeri]
MTWDVEYTDEFGDWWESLTADEQESIAVSVHLLEDRGPSLGFPHSSAINGSRHGHMRELRTQHNGRPIRTLYAFDPRRSA
ILLIGGDKTGDNRWYEINVPLADRLYDEHLEQLEKEG

Download         Length: 354 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12109.07 Da        Isoelectric Point: 8.6213

>AT287928 WP_037038764.1 NZ_LR134482:840818-841147 [Pseudomonas stutzeri]
MAKKFADLRAKMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLAELLHVQQPSIAKMEKRTDMYISTLRSHIEAMG
GQLEVIARFPDGSVKISNFAEIEAAAQQA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W9TFC1

References