Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1604826..1605495 Replicon chromosome
Accession NZ_LR134481
Organism Haemophilus parainfluenzae strain NCTC10665

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL215_RS08035 Protein ID WP_126471368.1
Coordinates 1605112..1605495 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag EL215_RS08030 Protein ID WP_005651224.1
Coordinates 1604826..1605128 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL215_RS08010 1600070..1600783 - 714 WP_126471364.1 phage minor tail protein L -
EL215_RS08015 1600783..1601109 - 327 WP_118867633.1 phage tail protein -
EL215_RS08020 1601109..1604522 - 3414 WP_126471366.1 tape measure protein -
EL215_RS08030 1604826..1605128 - 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
EL215_RS08035 1605112..1605495 - 384 WP_126471368.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL215_RS08040 1605564..1605788 - 225 WP_118809166.1 DUF4035 domain-containing protein -
EL215_RS08045 1605833..1606240 - 408 WP_126471370.1 hypothetical protein -
EL215_RS08050 1606298..1606951 - 654 WP_126471372.1 hypothetical protein -
EL215_RS08055 1606954..1607364 - 411 WP_005651206.1 phage tail protein -
EL215_RS08060 1607373..1607903 - 531 WP_126471374.1 phage tail protein -
EL215_RS08065 1607906..1608217 - 312 WP_126471376.1 hypothetical protein -
EL215_RS08070 1608198..1608521 - 324 WP_126471378.1 DUF2190 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14926.28 Da        Isoelectric Point: 5.0181

>T287927 WP_126471368.1 NZ_LR134481:c1605495-1605112 [Haemophilus parainfluenzae]
MKQEWEVILQDPLLNWLKMLAEDDVLKIYAALELLSTEGPQLSRPYADTLQSSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENERKI

Download         Length: 384 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT287927 WP_005651224.1 NZ_LR134481:c1605128-1604826 [Haemophilus parainfluenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References