Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1809877..1810490 Replicon chromosome
Accession NZ_LR134480
Organism Bordetella bronchiseptica strain NCTC8344

Toxin (Protein)


Gene name higB Uniprot ID K0MEM3
Locus tag EL399_RS08550 Protein ID WP_003811545.1
Coordinates 1809877..1810188 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL399_RS08555 Protein ID WP_003811547.1
Coordinates 1810191..1810490 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL399_RS08525 1805201..1805980 + 780 WP_033454573.1 SDR family oxidoreductase -
EL399_RS08530 1806093..1807019 + 927 WP_033461661.1 tripartite tricarboxylate transporter substrate binding protein -
EL399_RS08535 1807105..1808049 + 945 WP_080702971.1 LysR family transcriptional regulator -
EL399_RS08540 1808027..1808896 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
EL399_RS08545 1809140..1809763 + 624 WP_003811542.1 glutathione S-transferase family protein -
EL399_RS08550 1809877..1810188 + 312 WP_003811545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL399_RS08555 1810191..1810490 + 300 WP_003811547.1 helix-turn-helix domain-containing protein Antitoxin
EL399_RS08560 1810504..1813580 - 3077 Protein_1684 autotransporter SphB2 -
EL399_RS08565 1813710..1814384 + 675 WP_033449912.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11810.72 Da        Isoelectric Point: 8.8245

>T287924 WP_003811545.1 NZ_LR134480:1809877-1810188 [Bordetella bronchiseptica]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Download         Length: 312 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10946.70 Da        Isoelectric Point: 11.2467

>AT287924 WP_003811547.1 NZ_LR134480:1810191-1810490 [Bordetella bronchiseptica]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0MEM3

Antitoxin

Source ID Structure

References