Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 629345..630045 Replicon chromosome
Accession NZ_LR134480
Organism Bordetella bronchiseptica strain NCTC8344

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0H3LPJ8
Locus tag EL399_RS02975 Protein ID WP_003809515.1
Coordinates 629345..629641 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag EL399_RS02980 Protein ID WP_003809516.1
Coordinates 629644..630045 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL399_RS02955 625641..626183 + 543 WP_033469689.1 MOSC domain-containing protein -
EL399_RS02960 626359..627423 + 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
EL399_RS02965 627509..627955 - 447 WP_003809511.1 GFA family protein -
EL399_RS02970 628181..629062 + 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EL399_RS02975 629345..629641 + 297 WP_003809515.1 type II toxin-antitoxin system MqsR family toxin Toxin
EL399_RS02980 629644..630045 + 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EL399_RS02985 630065..630301 + 237 WP_003809519.1 hypothetical protein -
EL399_RS02990 630309..630788 + 480 WP_003809523.1 disulfide bond formation protein B -
EL399_RS02995 630936..631451 + 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
EL399_RS03000 631454..632644 + 1191 WP_003809527.1 5-(carboxyamino)imidazole ribonucleotide synthase -
EL399_RS03005 632664..633701 + 1038 WP_033454358.1 threonylcarbamoyl-AMP synthase -
EL399_RS03010 633838..634860 + 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10608.50 Da        Isoelectric Point: 7.9291

>T287923 WP_003809515.1 NZ_LR134480:629345-629641 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Download         Length: 297 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT287923 WP_003809516.1 NZ_LR134480:629644-630045 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3LPJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References