Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4670555..4671183 Replicon chromosome
Accession NZ_LR134478
Organism Serratia plymuthica strain NCTC8015

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL316_RS22305 Protein ID WP_119805070.1
Coordinates 4670555..4670845 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL316_RS22310 Protein ID WP_006320518.1
Coordinates 4670860..4671183 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL316_RS22295 4667117..4669138 + 2022 WP_126528807.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
EL316_RS22300 4669185..4670324 - 1140 WP_006320522.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
EL316_RS22305 4670555..4670845 + 291 WP_119805070.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL316_RS22310 4670860..4671183 + 324 WP_006320518.1 HigA family addiction module antidote protein Antitoxin
EL316_RS22315 4671176..4671688 + 513 WP_006320516.1 M48 family metallopeptidase -
EL316_RS22320 4671789..4672769 + 981 WP_126528808.1 Gfo/Idh/MocA family oxidoreductase -
EL316_RS22325 4672771..4673502 + 732 WP_126528809.1 glutamine amidotransferase -
EL316_RS22330 4673762..4674733 + 972 WP_172603412.1 TerC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11709.40 Da        Isoelectric Point: 10.2350

>T287919 WP_119805070.1 NZ_LR134478:4670555-4670845 [Serratia plymuthica]
MIKSFRDRYLEKFYREGRRNRLIPSPLERQLARKLDILAAAQKECDLHHPTGNYYKRLSGPFQGWSSMRVNMQWRLMFQW
RHDAAEQIYLDPHQDT

Download         Length: 291 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12186.88 Da        Isoelectric Point: 6.7197

>AT287919 WP_006320518.1 NZ_LR134478:4670860-4671183 [Serratia plymuthica]
MLETTTRKPTTVGEVLQEEYLTPLGIGQEDLAKVLGVTRATVNRLCNGHRRLSVAEANLFADLFETTADFWLNLQAAHDR
WEARQANMQRERLRPIMEILGRNVTHA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References