287917

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4246071..4246723 Replicon chromosome
Accession NZ_LR134478
Organism Serratia plymuthica strain NCTC8015

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL316_RS20335 Protein ID WP_126528667.1
Coordinates 4246071..4246415 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2X4V2M0
Locus tag EL316_RS20340 Protein ID WP_063200237.1
Coordinates 4246421..4246723 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL316_RS20320 4243299..4244318 + 1020 WP_004952299.1 HTH-type transcriptional regulator GalR -
EL316_RS20325 4244315..4244770 - 456 WP_126528665.1 GNAT family N-acetyltransferase -
EL316_RS20330 4244922..4245932 + 1011 WP_126528666.1 LacI family DNA-binding transcriptional regulator -
EL316_RS20335 4246071..4246415 + 345 WP_126528667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL316_RS20340 4246421..4246723 + 303 WP_063200237.1 helix-turn-helix transcriptional regulator Antitoxin
EL316_RS20345 4246753..4248015 - 1263 WP_126528668.1 diaminopimelate decarboxylase -
EL316_RS20350 4248152..4249075 + 924 WP_126484900.1 LysR family transcriptional regulator -
EL316_RS20355 4249065..4250219 - 1155 WP_126484902.1 MFS transporter -
EL316_RS20360 4250534..4251442 - 909 WP_126484904.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13343.36 Da        Isoelectric Point: 9.7587

>T287917 WP_126528667.1 NZ_LR134478:4246071-4246415 [Serratia plymuthica]
MWQVVTVERFDDWFLSLNSDEQKSLLAGIFKLQEFGPLLARPHADTLHFSGSIRHLKELRIQHHGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRLLPIAAMEFSHYLATQR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11126.05 Da        Isoelectric Point: 10.1425

>AT287917 WP_063200237.1 NZ_LR134478:4246421-4246723 [Serratia plymuthica]
MAKPLSNLIDKLDPTVVAAARQKAEKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVELPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4V2M0

References