287916

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3960036..3961375 Replicon chromosome
Accession NZ_LR134478
Organism Serratia plymuthica strain NCTC8015

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag EL316_RS19015 Protein ID WP_126528582.1
Coordinates 3960344..3961375 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A1B1KUV7
Locus tag EL316_RS19010 Protein ID WP_006318221.1
Coordinates 3960036..3960347 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL316_RS18980 3955289..3956089 - 801 WP_126528577.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
EL316_RS18985 3956086..3956880 - 795 WP_126528578.1 hydroxyethylthiazole kinase -
EL316_RS18990 3957077..3957502 + 426 WP_126484547.1 GNAT family N-acetyltransferase -
EL316_RS18995 3957665..3958906 - 1242 WP_126528579.1 MFS transporter -
EL316_RS19000 3959000..3959443 + 444 WP_126528580.1 helix-turn-helix transcriptional regulator -
EL316_RS19005 3959704..3960051 + 348 WP_126528581.1 XRE family transcriptional regulator -
EL316_RS19010 3960036..3960347 + 312 WP_006318221.1 HipA N-terminal domain-containing protein Antitoxin
EL316_RS19015 3960344..3961375 + 1032 WP_126528582.1 HipA domain-containing protein Toxin
EL316_RS19020 3961437..3962198 + 762 WP_126528583.1 23S rRNA pseudouridine(2604) synthase RluF -
EL316_RS19025 3962268..3965321 - 3054 WP_126528584.1 autotransporter outer membrane beta-barrel domain-containing protein -
EL316_RS19030 3965552..3965866 - 315 WP_006327281.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3960036..3977804 17768


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 38577.33 Da        Isoelectric Point: 6.1119

>T287916 WP_126528582.1 NZ_LR134478:3960344-3961375 [Serratia plymuthica]
MNPDRCLINLTPLKAPELITGYSKQGIKQLFGSAKIALTLPFTRREFIQELPERQKGMSISGYQPKLSLSLEEGELRVVN
NDGTYILKPSPEEYPHLAENEHATMTVMARLKFVVPPFGLMRFKADEDRPDELAFVIKRYDRIGPDRVRLHQEQLDGAMG
INDKYGYVDGKKDISYEKAAKFLNHTVSNGLSSKRDVFLRILYAYVLGNNDFHLRNLGIIHPENASPYVAPVYDFISVAP
YPAAFGEYLALPLLECEENDAGIAPGINSPYGEYIGVDFILLAEGMDVNPKLAKKWLAEVVKSHQLIIDTYTESHMPAEQ
REAVLSYVARRITLLGVTELKTA

Download         Length: 1032 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11775.50 Da        Isoelectric Point: 5.8715

>AT287916 WP_006318221.1 NZ_LR134478:3960036-3960347 [Serratia plymuthica]
MARKIEVWLYGKAVGSLTEEKEGYTFGYYSGYSGPAVSLSMRVRPEPYFSEELHPFFKGLAPEGWLRKRYAEIQKIDDRD
LFGLLMQNGNDLLGAVVFKEMSP

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KUV7

References