Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1984203..1984709 Replicon chromosome
Accession NZ_LR134477
Organism Actinomyces viscosus strain NCTC10951

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag EL340_RS08495 Protein ID WP_126414243.1
Coordinates 1984203..1984358 (+) Length 52 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag EL340_RS08500 Protein ID WP_126414244.1
Coordinates 1984404..1984709 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL340_RS08475 1979453..1981177 - 1725 WP_126414239.1 MFS transporter -
EL340_RS08480 1981248..1981973 - 726 WP_126414240.1 TetR/AcrR family transcriptional regulator -
EL340_RS08485 1982258..1982644 - 387 WP_126414241.1 VOC family protein -
EL340_RS08490 1982684..1984123 - 1440 WP_126414242.1 NAD(P)/FAD-dependent oxidoreductase -
EL340_RS08495 1984203..1984358 + 156 WP_126414243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL340_RS08500 1984404..1984709 + 306 WP_126414244.1 helix-turn-helix domain-containing protein Antitoxin
EL340_RS08505 1984764..1985561 - 798 WP_126414245.1 sulfite exporter TauE/SafE family protein -
EL340_RS08510 1985568..1986965 - 1398 WP_126414246.1 anaerobic sulfatase maturase -
EL340_RS08515 1986962..1988128 - 1167 WP_126414247.1 ROK family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-43)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5567.31 Da        Isoelectric Point: 6.7194

>T287898 WP_126414243.1 NZ_LR134477:1984203-1984358 [Actinomyces viscosus]
VRSVDIELVAAWLASLDSSSQAQVVAAIELLEEQGPHLGRPLRQAKHPHSR

Download         Length: 156 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11538.06 Da        Isoelectric Point: 6.4763

>AT287898 WP_126414244.1 NZ_LR134477:1984404-1984709 [Actinomyces viscosus]
MPMTITEFLDTHPVSRDQIEAHKERMRTEIRAYRLRELREQAGLTQAQLADRIGVGQRQVSKIERGDLDDSKIGTIRRYL
EAVGGDLAIEYVTGDQRVQVA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References