Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 976731..977246 Replicon chromosome
Accession NZ_LR134473
Organism Acidipropionibacterium jensenii strain NCTC13652

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3S4V1K2
Locus tag EL292_RS04440 Protein ID WP_028702688.1
Coordinates 976731..976985 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A3S4UWW3
Locus tag EL292_RS04445 Protein ID WP_028702687.1
Coordinates 976986..977246 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL292_RS04410 971797..972324 - 528 WP_197720493.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
EL292_RS04415 972321..972698 - 378 WP_051238192.1 DUF1801 domain-containing protein -
EL292_RS14450 972785..973084 - 300 WP_197720494.1 hypothetical protein -
EL292_RS14455 973127..973384 - 258 WP_197720495.1 hypothetical protein -
EL292_RS04425 973401..975281 - 1881 WP_197720511.1 ABC transporter ATP-binding protein/permease -
EL292_RS04430 975325..975690 - 366 WP_154655309.1 hypothetical protein -
EL292_RS04435 975942..976481 - 540 WP_028702689.1 GNAT family N-acetyltransferase -
EL292_RS04440 976731..976985 - 255 WP_028702688.1 Txe/YoeB family addiction module toxin Toxin
EL292_RS04445 976986..977246 - 261 WP_028702687.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EL292_RS04450 977528..977920 - 393 WP_197720512.1 HigA family addiction module antidote protein -
EL292_RS04465 978335..978982 - 648 WP_197720496.1 TetR/AcrR family transcriptional regulator -
EL292_RS04470 979070..980827 + 1758 WP_028702685.1 oleate hydratase -
EL292_RS04475 981123..981602 - 480 WP_197720497.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 981792..982796 1004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9970.31 Da        Isoelectric Point: 7.2747

>T287889 WP_028702688.1 NZ_LR134473:c976985-976731 [Acidipropionibacterium jensenii]
VRLVWDPSAWEDYTHWQTIDRRVLKRVNTLIDSCLREPFAGIGKPEQLKYGAQGAWSRRITDEHRLVYLVDGDDLVILQA
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9780.93 Da        Isoelectric Point: 4.8839

>AT287889 WP_028702687.1 NZ_LR134473:c977246-976986 [Acidipropionibacterium jensenii]
MSISASEARRTLFPLIERINEDREAIEIVSRKGNAVLMPADEYTAWQETAYLFRSPANARRLLDAYERARAGKVETHALD
RADEDA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S4V1K2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S4UWW3

References