Detailed information of TA system TA287881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-VapI
• Location: 712573..713162
• Replicon: chromosome
• Accession: NZ_LR134442
• Organism: Propionibacterium australiense strain NCTC13651

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: EL282_RS03085
• Protein ID: WP_119161924.1
• Coordinates: 712573..712854 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EL282_RS03090
• Protein ID: WP_119161923.1
• Coordinates: 712863..713162 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL282_RS03055	708055..709911	+	1857	WP_119161928.1	ABC transporter ATP-binding protein/permease	-
EL282_RS03060	710264..711337	+	1074	WP_119161927.1	redox-regulated ATPase YchF	-
EL282_RS03070	711584..712012	-	429	WP_119161926.1	type II toxin-antitoxin system VapC family toxin	-
EL282_RS03075	712009..712248	-	240	WP_119161925.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EL282_RS03080	712368..712541	+	174	Protein_606	DUF933 domain-containing protein	-
EL282_RS03085	712573..712854	+	282	WP_119161924.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EL282_RS03090	712863..713162	+	300	WP_119161923.1	HigA family addiction module antidote protein	Antitoxin
EL282_RS03095	713301..713420	+	120	Protein_609	DUF933 domain-containing protein	-
EL282_RS03100	713524..714777	+	1254	WP_119161922.1	ATP-binding protein	-
EL282_RS03105	715171..716652	+	1482	WP_119161921.1	DUF3375 domain-containing protein	-
EL282_RS03110	716645..717364	+	720	WP_119161920.1	DUF4194 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	698145..714777	16632

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-96)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10757.17 Da
• Isoelectric Point: 10.0891

>T287881 WP_119161924.1 NZ_LR134442:712573-712854 [Propionibacterium australiense]
VIRSFGDRDTELVWLREPARRIDPRVHKTANRKLHQLDAAVSLNSLRVPPGNHLEALRGDRKGQHSIRINDQWRICFVWT
AAGPENGIIEDYH

Nucleotide

• Length: 282 bp

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11077.77 Da
• Isoelectric Point: 6.4827

>AT287881 WP_119161923.1 NZ_LR134442:712863-713162 [Propionibacterium australiense]
MAEKLYAPIHPGEVLMEDFINAFGITQHKLAVSIGVPPRRINEIVHGKRAITADTALRLGRYFGVEPQFWLNLQSRYELE
LAEDRAAGELDAIKPIHAA

Nucleotide

• Length: 300 bp