Detailed information of TA system TA287880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 585183..585703
• Replicon: chromosome
• Accession: NZ_LR134442
• Organism: Propionibacterium australiense strain NCTC13651

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: EL282_RS02445
• Protein ID: WP_119161597.1
• Coordinates: 585443..585703 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EL282_RS02440
• Protein ID: WP_119161598.1
• Coordinates: 585183..585440 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL282_RS02425	581516..582697	-	1182	WP_119161601.1	galactokinase	-
EL282_RS02430	582903..584609	+	1707	WP_119161600.1	sodium:solute symporter family protein	-
EL282_RS02435	584623..584895	+	273	WP_119161599.1	hypothetical protein	-
EL282_RS02440	585183..585440	+	258	WP_119161598.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EL282_RS02445	585443..585703	+	261	WP_119161597.1	Txe/YoeB family addiction module toxin	Toxin
EL282_RS02450	586160..586513	+	354	WP_119161596.1	cupin domain-containing protein	-
EL282_RS02455	586552..587334	+	783	WP_119161595.1	SDR family oxidoreductase	-
EL282_RS02460	587345..588214	+	870	WP_170175648.1	acetoacetate decarboxylase family protein	-
EL282_RS02465	588258..589778	+	1521	WP_119161593.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10234.61 Da
• Isoelectric Point: 9.4963

>T287880 WP_119161597.1 NZ_LR134442:585443-585703 [Propionibacterium australiense]
VLLVWDENAWDDYLWWRAQDRTGLKRINRLIVDVARNGNEGIGKPEALRHGLAGYWSRRITDEHRLVYRIDGERILVAAC
RYHYGR

Nucleotide

• Length: 261 bp

>T287880 NZ_LR134442:585443-585703 [Propionibacterium australiense]
GTGCTCCTCGTCTGGGACGAGAACGCCTGGGACGACTATCTGTGGTGGCGGGCCCAGGACCGCACGGGGCTCAAGCGCAT
CAACCGTCTCATCGTCGACGTGGCGCGCAACGGCAACGAGGGCATCGGCAAGCCCGAGGCACTGCGGCACGGCCTCGCCG
GCTACTGGTCGCGGCGGATCACCGACGAGCACCGGCTCGTCTACAGGATCGACGGTGAACGCATCCTCGTCGCTGCCTGT
CGCTACCACTACGGACGTTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9544.73 Da
• Isoelectric Point: 4.6882

>AT287880 WP_119161598.1 NZ_LR134442:585183-585440 [Propionibacterium australiense]
MKTISYTESRARYAEVLDAVTDNREEVIITRAGHEPVVMISLADYESLRETACLMRSPENSRRLLDAVERLESGGGRPHE
LLPGD

Nucleotide

• Length: 258 bp

>AT287880 NZ_LR134442:585183-585440 [Propionibacterium australiense]
ATGAAGACGATCAGCTACACCGAATCACGGGCGCGGTACGCCGAGGTGCTTGATGCGGTCACCGACAACCGCGAGGAGGT
CATCATCACCCGGGCCGGGCACGAGCCAGTCGTCATGATCTCGCTCGCCGATTACGAATCGCTGCGCGAGACGGCCTGTC
TGATGCGTTCCCCGGAGAACTCCAGGCGGCTGCTCGACGCGGTGGAACGTCTCGAGTCCGGTGGCGGGCGCCCGCACGAG
CTCCTCCCCGGGGACTGA