287874

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 257975..259212 Replicon plasmid 9
Accession NZ_LR134418
Organism Legionella adelaidensis strain NCTC12735

Toxin (Protein)


Gene name HipT Uniprot ID A0A0W0R598
Locus tag EL206_RS02380 Protein ID WP_058461949.1
Coordinates 258280..259212 (+) Length 311 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0W0R5A3
Locus tag EL206_RS02375 Protein ID WP_058461948.1
Coordinates 257975..258283 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL206_RS02340 253441..254076 + 636 WP_058461942.1 class I SAM-dependent methyltransferase -
EL206_RS02345 254080..254523 + 444 WP_058461943.1 GNAT family N-acetyltransferase -
EL206_RS02350 254606..255286 + 681 WP_058461944.1 thiopurine S-methyltransferase -
EL206_RS02355 255297..255659 + 363 WP_058461945.1 VOC family protein -
EL206_RS02365 256248..256778 - 531 WP_058461946.1 acetyltransferase -
EL206_RS02370 257751..257978 + 228 WP_058461947.1 helix-turn-helix transcriptional regulator -
EL206_RS02375 257975..258283 + 309 WP_058461948.1 HipA N-terminal domain-containing protein Antitoxin
EL206_RS02380 258280..259212 + 933 WP_058461949.1 lpg2370 family Dot/Icm T4SS effector Toxin
EL206_RS02385 259660..260505 - 846 WP_058461950.1 class I SAM-dependent methyltransferase -
EL206_RS02390 260900..261391 - 492 WP_058461951.1 hypothetical protein -
EL206_RS02395 261655..262536 + 882 WP_058461952.1 GNAT family N-acetyltransferase -
EL206_RS02400 262756..263256 + 501 WP_058461953.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pilE / ankH/legA3/ankW / pilT / enhA / lpg2359 / lpg2370 / lirB 1..451287 451287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-277)

Antitoxin

HipA, N-terminal subdomain 1

(3-98)


Sequences

Toxin        


Download         Length: 311 a.a.        Molecular weight: 35820.68 Da        Isoelectric Point: 9.7405

>T287874 WP_058461949.1 NZ_LR134418:258280-259212 [Legionella adelaidensis]
MKHCPITYEKISVQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKAGCFEIVDQYG
QYILKPQSDIYPELPENEALTMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIAQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKERKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFALEKLGLNQNVTDRIVQEFHQVIPKWQELIGFSFLSQPMQEKYLELLEQRRKRLFE

Download         Length: 933 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11593.50 Da        Isoelectric Point: 4.5994

>AT287874 WP_058461948.1 NZ_LR134418:257975-258283 [Legionella adelaidensis]
MRKAYVSVNGIRAGILEELEGKKYQFTYLTDYQGAPVSLTMPLTNKIYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKHD
YFGQLIIVGQDVVGAVTIEEVI

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0R598

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0R5A3

References