287861

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1783207..1784536 Replicon chromosome
Accession NZ_LR134396
Organism Providencia rustigianii strain NCTC8113

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag EL244_RS08265 Protein ID WP_126460105.1
Coordinates 1783207..1784229 (-) Length 341 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID D1NZB1
Locus tag EL244_RS08270 Protein ID WP_006813160.1
Coordinates 1784222..1784536 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL244_RS08245 1779108..1780619 + 1512 WP_126460096.1 alanine:cation symporter family protein -
EL244_RS08255 1781066..1782007 + 942 WP_126460099.1 glyoxylate/hydroxypyruvate reductase GhrA -
EL244_RS08260 1782577..1783131 + 555 WP_126460102.1 molecular chaperone -
EL244_RS08265 1783207..1784229 - 1023 WP_126460105.1 HipA domain-containing protein Toxin
EL244_RS08270 1784222..1784536 - 315 WP_006813160.1 HipA N-terminal domain-containing protein Antitoxin
EL244_RS08275 1784521..1784766 - 246 WP_006813159.1 hypothetical protein -
EL244_RS08280 1785019..1785579 - 561 WP_006813158.1 lipoprotein -
EL244_RS08285 1785619..1786824 - 1206 WP_006813157.1 multidrug efflux MFS transporter MdtH -
EL244_RS08290 1787151..1789391 + 2241 WP_126460108.1 PAAR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-301)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 341 a.a.        Molecular weight: 38490.25 Da        Isoelectric Point: 6.7648

>T287861 WP_126460105.1 NZ_LR134396:c1784229-1783207 [Providencia rustigianii]
MNEKHCLINLKKLNNEELEFGYSQAGINELFGKNSPALELPFTRSQFIQDQPANQTGMSISGFQPKLSLRLENGSLYVAN
NKGTFILKPSPEAYPFLAENEHATMTVMKRLKFPTPPFGLIPFQSSLDKPKEFAFIIQRYDRLGNDVQKLHQEQLDGAMG
INDKYGNVDGTKSVSYEKAAKFIIENVDDSLASKRDLFLRIIYAYVLGNNDYHLRNISILLPQNKKPSLAPIYDFVSIVP
YPSVFTEYLALPLLELEENDSDIAPGLNSQYGEYTGADFILLAQGIGIRNELAKKLLLRVIKSHQLITDTYTESHLPDVD
KLAIIKYISRRMTLLGIMRF

Download         Length: 1023 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11960.63 Da        Isoelectric Point: 5.0746

>AT287861 WP_006813160.1 NZ_LR134396:c1784536-1784222 [Providencia rustigianii]
MSRKVEVWLYNIPVGILAEVTNGYSFQYYQHYDGQSVSLSMGVRSEPYLCDELHPFFKGLAPEGWLKKRYSELQKIDPND
LFGMLIQNGNDLLGAITFKEIAHE

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A379G3C9

References