Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1480930..1481655 Replicon chromosome
Accession NZ_LR134396
Organism Providencia rustigianii strain NCTC8113

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL244_RS06635 Protein ID WP_126459617.1
Coordinates 1481350..1481655 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL244_RS06630 Protein ID WP_006813416.1
Coordinates 1480930..1481346 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL244_RS06615 1476997..1477974 + 978 WP_006813419.1 flagellar assembly peptidoglycan hydrolase FlgJ -
EL244_RS06620 1478113..1479756 + 1644 WP_006813418.1 flagellar hook-associated protein FlgK -
EL244_RS06625 1479805..1480740 + 936 WP_039854240.1 flagellar hook-associated protein FlgL -
EL244_RS06630 1480930..1481346 - 417 WP_006813416.1 helix-turn-helix domain-containing protein Antitoxin
EL244_RS06635 1481350..1481655 - 306 WP_126459617.1 type II toxin-antitoxin system HigB family toxin Toxin
EL244_RS06640 1481976..1482755 - 780 WP_006813414.1 flagellar type III secretion system protein FliR -
EL244_RS06645 1482758..1483027 - 270 WP_126459620.1 flagellar biosynthesis protein FliQ -
EL244_RS06650 1483036..1483779 - 744 WP_006813412.1 flagellar type III secretion system pore protein FliP -
EL244_RS06655 1483792..1484268 - 477 WP_126459623.1 flagellar biosynthetic protein FliO -
EL244_RS06660 1484270..1484686 - 417 WP_006813410.1 flagellar motor switch protein FliN -
EL244_RS06665 1484679..1485686 - 1008 WP_006813409.1 flagellar motor switch protein FliM -
EL244_RS06670 1485692..1486174 - 483 WP_006813408.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12104.08 Da        Isoelectric Point: 10.4596

>T287860 WP_126459617.1 NZ_LR134396:c1481655-1481350 [Providencia rustigianii]
MHVISREPFVHASERNPKHAKVLLDVYKTLKQGSYSSPDELKNIFPSLDRMKYREKWWVIDIGGNALRILFFADFKKSKI
FIKHISTHAEYNKLMNYYRRT

Download         Length: 306 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 16096.38 Da        Isoelectric Point: 5.2536

>AT287860 WP_006813416.1 NZ_LR134396:c1481346-1480930 [Providencia rustigianii]
MIFSEAIQTANHLIHLIPILGKNHSRRDYEDAIKLVEYLVEYDPDNPLVEILCEKIDHYEDNAPEFADFNRKLKQCDDAV
AVLRTLMDQYNLNTTDFANEIGSRSYVSRILNGERNLSLEHMKKLAERFKLPVTIFIK

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References