Detailed information of TA system TA028786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2984607..2985120
• Replicon: chromosome
• Accession: NC_020156
• Organism: Nonlabens dokdonensis DSW-6

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: L7W869
• Locus tag: DDD_RS13030
• Protein ID: WP_015363372.1
• Coordinates: 2984607..2984864 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: L7WD77
• Locus tag: DDD_RS13035
• Protein ID: WP_015363373.1
• Coordinates: 2984866..2985120 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDD_RS17330	2979632..2980231	-	600	WP_052329288.1	hypothetical protein	-
DDD_RS13020	2980528..2982549	-	2022	WP_015363369.1	tetratricopeptide repeat protein	-
DDD_RS18030	2982918..2983055	+	138	WP_015363370.1	hypothetical protein	-
DDD_RS13025	2983063..2984304	+	1242	WP_015363371.1	capsular polysaccharide biosynthesis protein	-
DDD_RS13030	2984607..2984864	-	258	WP_015363372.1	Txe/YoeB family addiction module toxin	Toxin
DDD_RS13035	2984866..2985120	-	255	WP_015363373.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DDD_RS13040	2985333..2985632	+	300	WP_015363374.1	hypothetical protein	-
DDD_RS13045	2985670..2986869	+	1200	WP_015363375.1	glycosyltransferase	-
DDD_RS13050	2987312..2988820	-	1509	WP_015363376.1	cellulase family glycosylhydrolase	-
DDD_RS13055	2988817..2990052	-	1236	WP_146250824.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10585.16 Da
• Isoelectric Point: 9.5407

>T28786 WP_015363372.1 NC_020156:c2984864-2984607 [Nonlabens dokdonensis DSW-6]
MRYVFVDESWEDYLYWQKTDKKKLKKINELLKDIARNPFDGIGKPEPLKHKYAGFWSRRIDSEHRLIYQYRENEILIAKC
RFHYD

Nucleotide

• Length: 258 bp

>T28786 NC_020156:c2984864-2984607 [Nonlabens dokdonensis DSW-6]
ATGAGGTATGTTTTCGTAGACGAATCTTGGGAAGATTATTTGTACTGGCAAAAGACAGATAAGAAAAAACTGAAGAAAAT
AAATGAACTTCTTAAAGACATCGCTAGAAATCCTTTTGACGGAATAGGAAAACCAGAACCATTAAAACATAAATACGCAG
GTTTTTGGTCCAGACGAATTGATAGCGAACATAGACTCATCTACCAATACCGAGAAAACGAAATTTTGATTGCAAAATGC
AGATTTCATTATGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9652.01 Da
• Isoelectric Point: 5.0628

>AT28786 WP_015363373.1 NC_020156:c2985120-2984866 [Nonlabens dokdonensis DSW-6]
MQITTVSDFRKDLKTYLDRVVMNFETLLINRGKDAGIVVMSLQEYNSLMATNHELSSRKNELRLDAAIDKLKNGTTFNQD
LIED

Nucleotide

• Length: 255 bp

>AT28786 NC_020156:c2985120-2984866 [Nonlabens dokdonensis DSW-6]
ATGCAAATAACAACCGTTTCTGATTTTAGAAAAGACCTTAAGACTTACTTAGACCGAGTTGTAATGAACTTTGAGACCTT
GCTCATCAATCGTGGCAAAGATGCTGGAATTGTAGTGATGTCATTACAAGAGTACAATTCTTTAATGGCTACAAATCACG
AGCTTTCTTCAAGAAAAAATGAATTGAGATTAGATGCTGCTATAGACAAGTTAAAAAACGGAACTACGTTTAATCAAGAC
CTCATAGAAGATTAA

Structures

Toxin

• AlphaFold DB: L7W869

Antitoxin

• AlphaFold DB: L7WD77