Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 602987..603676 Replicon chromosome
Accession NZ_LR134396
Organism Providencia rustigianii strain NCTC8113

Toxin (Protein)


Gene name higB Uniprot ID D1P6V8
Locus tag EL244_RS02720 Protein ID WP_006815972.1
Coordinates 602987..603307 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL244_RS02725 Protein ID WP_039855724.1
Coordinates 603344..603676 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL244_RS02705 598219..599232 + 1014 WP_006815975.1 mechanosensitive ion channel family protein -
EL244_RS02710 599505..601664 + 2160 WP_126458567.1 ornithine decarboxylase -
EL244_RS02715 601764..602699 + 936 WP_126458570.1 nucleoside hydrolase -
EL244_RS02720 602987..603307 + 321 WP_006815972.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL244_RS02725 603344..603676 + 333 WP_039855724.1 HigA family addiction module antidote protein Antitoxin
EL244_RS02730 603789..604814 + 1026 WP_126458573.1 tRNA dihydrouridine(20/20a) synthase DusA -
EL244_RS17875 604916..605089 + 174 WP_172597495.1 hypothetical protein -
EL244_RS02735 605135..606118 - 984 WP_126458576.1 quinone oxidoreductase -
EL244_RS02740 606328..607737 + 1410 WP_006815966.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-70)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12700.77 Da        Isoelectric Point: 8.4429

>T287856 WP_006815972.1 NZ_LR134396:602987-603307 [Providencia rustigianii]
MEEVYVNEDNDCRLIFRDEYLRLFYVYGKLHRLIPSIICTVLARKLDMLNAAKTLQDFKSPPGNRFKQLKPPLEEFYSIR
VNGQYRLIFKWKDTVEGLYLDPHKDV

Download         Length: 321 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12698.66 Da        Isoelectric Point: 7.4004

>AT287856 WP_039855724.1 NZ_LR134396:603344-603676 [Providencia rustigianii]
MMQATRKPASVGDILLYEYLLPTGMKIHELAELLGVHRNTVSSLINNNRKLSTDMAFKLAKAFGTSKQFWINLQQALDIW
EVENDPRLQEEISHILHYEDFLKQKSQKVA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D1P6V8

Antitoxin

Source ID Structure

References