Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1666969..1667608 Replicon chromosome
Accession NZ_LR134395
Organism Haemophilus aegyptius strain NCTC8134

Toxin (Protein)


Gene name higB Uniprot ID Q4QJX7
Locus tag EL190_RS08715 Protein ID WP_005650215.1
Coordinates 1667303..1667608 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL190_RS08710 Protein ID WP_005650217.1
Coordinates 1666969..1667292 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL190_RS10255 1662589..1662762 - 174 WP_005657572.1 DUF5363 domain-containing protein -
EL190_RS08695 1662759..1664729 - 1971 WP_006995880.1 tRNA(Met) cytidine acetyltransferase TmcA -
EL190_RS08700 1664734..1665075 - 342 WP_006995879.1 SirB2 family protein -
EL190_RS08705 1665136..1666806 - 1671 WP_005663485.1 energy-dependent translational throttle protein EttA -
EL190_RS08710 1666969..1667292 - 324 WP_005650217.1 HigA family addiction module antidote protein Antitoxin
EL190_RS08715 1667303..1667608 - 306 WP_005650215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL190_RS08720 1667933..1668553 + 621 WP_005694310.1 zinc transporter binding subunit ZevA -
EL190_RS08725 1668556..1669530 + 975 WP_006995878.1 zinc transporter permease subunit ZevB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12301.93 Da        Isoelectric Point: 9.0853

>T287855 WP_005650215.1 NZ_LR134395:c1667608-1667303 [Haemophilus aegyptius]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT287855 WP_005650217.1 NZ_LR134395:c1667292-1666969 [Haemophilus aegyptius]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806EC70

Antitoxin

Source ID Structure

References