Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1632204..1632847 Replicon chromosome
Accession NZ_LR134395
Organism Haemophilus aegyptius strain NCTC8134

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL190_RS08560 Protein ID WP_006995912.1
Coordinates 1632204..1632542 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL190_RS08565 Protein ID WP_006995911.1
Coordinates 1632539..1632847 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL190_RS08535 1627814..1628185 + 372 WP_006995917.1 hypothetical protein -
EL190_RS08540 1628175..1628378 + 204 WP_006995916.1 hypothetical protein -
EL190_RS08545 1628365..1629048 + 684 WP_006995915.1 hypothetical protein -
EL190_RS08550 1629041..1629433 + 393 WP_006995914.1 hypothetical protein -
EL190_RS08555 1629421..1631613 + 2193 WP_006995913.1 DUF927 domain-containing protein -
EL190_RS08560 1632204..1632542 + 339 WP_006995912.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL190_RS08565 1632539..1632847 + 309 WP_006995911.1 helix-turn-helix domain-containing protein Antitoxin
EL190_RS08570 1633178..1633697 - 520 Protein_1639 DDE-type integrase/transposase/recombinase -
EL190_RS08575 1633769..1634443 - 675 WP_006995908.1 N-acylneuraminate cytidylyltransferase -
EL190_RS08580 1634557..1635219 + 663 WP_006995907.1 NAD(P)H-dependent oxidoreductase -
EL190_RS08585 1635258..1635611 - 354 WP_006995906.1 type II toxin-antitoxin system PemK/MazF family toxin -
EL190_RS08590 1635611..1635880 - 270 WP_006995905.1 hypothetical protein -
EL190_RS08595 1636103..1637215 - 1113 WP_006995904.1 iron-sulfur cluster carrier protein ApbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1620062..1632847 12785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-80)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13134.05 Da        Isoelectric Point: 9.2488

>T287854 WP_006995912.1 NZ_LR134395:1632204-1632542 [Haemophilus aegyptius]
VKLSFIELPPFERYRKAHLSDDEYRAFQNELLENPEKGDVIQNAGGLRKIRIADSERNKGKRGGARVIYYYLIRKSQILL
VTAYSKNRCEDLTTEQYKILAKLVKEIEELEQ

Download         Length: 339 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11550.34 Da        Isoelectric Point: 9.9619

>AT287854 WP_006995911.1 NZ_LR134395:1632539-1632847 [Haemophilus aegyptius]
MSKLFDELIEGLNAYKDFTQGKITLRVETRERIEPASITAEEVKAIREKLNLSQAVFAQKLRTSVRTYQGWEQGKTKPSA
HASLLLRMVDKAPQTFELIAGI

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References