Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1632204..1632847 Replicon chromosome
Accession NZ_LR134395
Organism Haemophilus aegyptius strain NCTC8134

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL190_RS08560 Protein ID WP_006995912.1
Coordinates 1632204..1632542 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL190_RS08565 Protein ID WP_006995911.1
Coordinates 1632539..1632847 (+) Length 103 a.a.

Genomic Context

EL190_RS08535EL190_RS08540EL190_RS08545EL190_RS08550EL190_RS08555EL190_RS08560EL190_RS08565EL190_RS08580EL190_RS08570EL190_RS08575EL190_RS08585EL190_RS08590EL190_RS08595
Location: 1627814..1628185 (372 bp)
Type: Others
Protein ID: WP_006995917.1
Location: 1628175..1628378 (204 bp)
Type: Others
Protein ID: WP_006995916.1
Location: 1628365..1629048 (684 bp)
Type: Others
Protein ID: WP_006995915.1
Location: 1629041..1629433 (393 bp)
Type: Others
Protein ID: WP_006995914.1
Location: 1629421..1631613 (2193 bp)
Type: Others
Protein ID: WP_006995913.1
Location: 1632204..1632542 (339 bp)
Type: Toxin
Protein ID: WP_006995912.1
Location: 1632539..1632847 (309 bp)
Type: Antitoxin
Protein ID: WP_006995911.1
Location: 1634557..1635219 (663 bp)
Type: Others
Protein ID: WP_006995907.1
Location: 1633178..1633697 (520 bp)
Type: Others
Protein ID: Protein_1639
Location: 1633769..1634443 (675 bp)
Type: Others
Protein ID: WP_006995908.1
Location: 1635258..1635611 (354 bp)
Type: Others
Protein ID: WP_006995906.1
Location: 1635611..1635880 (270 bp)
Type: Others
Protein ID: WP_006995905.1
Location: 1636103..1637215 (1113 bp)
Type: Others
Protein ID: WP_006995904.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL190_RS085351627814..1628185+372WP_006995917.1hypothetical protein-
EL190_RS085401628175..1628378+204WP_006995916.1hypothetical protein-
EL190_RS085451628365..1629048+684WP_006995915.1hypothetical protein-
EL190_RS085501629041..1629433+393WP_006995914.1hypothetical protein-
EL190_RS085551629421..1631613+2193WP_006995913.1DUF927 domain-containing protein-
EL190_RS085601632204..1632542+339WP_006995912.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EL190_RS085651632539..1632847+309WP_006995911.1helix-turn-helix domain-containing proteinAntitoxin
EL190_RS085701633178..1633697-520Protein_1639DDE-type integrase/transposase/recombinase-
EL190_RS085751633769..1634443-675WP_006995908.1N-acylneuraminate cytidylyltransferase-
EL190_RS085801634557..1635219+663WP_006995907.1NAD(P)H-dependent oxidoreductase-
EL190_RS085851635258..1635611-354WP_006995906.1type II toxin-antitoxin system PemK/MazF family toxin-
EL190_RS085901635611..1635880-270WP_006995905.1hypothetical protein-
EL190_RS085951636103..1637215-1113WP_006995904.1iron-sulfur cluster carrier protein ApbC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1620062..163284712785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-80)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13134.05 Da        Isoelectric Point: 9.2488

>T287854 WP_006995912.1 NZ_LR134395:1632204-1632542 [Haemophilus aegyptius]
VKLSFIELPPFERYRKAHLSDDEYRAFQNELLENPEKGDVIQNAGGLRKIRIADSERNKGKRGGARVIYYYLIRKSQILL
VTAYSKNRCEDLTTEQYKILAKLVKEIEELEQ

Download         Length: 339 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11550.34 Da        Isoelectric Point: 9.9619

>AT287854 WP_006995911.1 NZ_LR134395:1632539-1632847 [Haemophilus aegyptius]
MSKLFDELIEGLNAYKDFTQGKITLRVETRERIEPASITAEEVKAIREKLNLSQAVFAQKLRTSVRTYQGWEQGKTKPSA
HASLLLRMVDKAPQTFELIAGI

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References