287852

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 494664..496012 Replicon chromosome
Accession NZ_LR134395
Organism Haemophilus aegyptius strain NCTC8134

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag EL190_RS02655 Protein ID WP_006995245.1
Coordinates 494981..496012 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag EL190_RS02650 Protein ID WP_006995246.1
Coordinates 494664..494984 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL190_RS02610 489887..490165 + 279 WP_006995251.1 cell division protein FtsB -
EL190_RS02615 490165..490842 + 678 WP_006995250.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
EL190_RS02620 490839..491315 + 477 WP_006995249.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
EL190_RS10180 491385..491552 - 168 WP_006995248.1 hypothetical protein -
EL190_RS02625 491819..492253 - 435 WP_006995247.1 D-tyrosyl-tRNA(Tyr) deacylase -
EL190_RS02630 492250..492690 - 441 WP_005667635.1 FMN-binding protein MioC -
EL190_RS02635 492787..493005 - 219 WP_005650820.1 cell division protein ZapB -
EL190_RS02640 493167..494168 + 1002 WP_005672749.1 class II fructose-bisphosphatase -
EL190_RS02645 494368..494676 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
EL190_RS02650 494664..494984 + 321 WP_006995246.1 type II toxin-antitoxin system HipA family toxin Antitoxin
EL190_RS02655 494981..496012 + 1032 WP_006995245.1 type II toxin-antitoxin system HipA family toxin Toxin
EL190_RS02660 496096..497754 - 1659 WP_006995244.1 thiol reductant ABC exporter subunit CydC -
EL190_RS02665 497747..499492 - 1746 WP_006995243.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39718.31 Da        Isoelectric Point: 6.5777

>T287852 WP_006995245.1 NZ_LR134395:494981-496012 [Haemophilus aegyptius]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12452.13 Da        Isoelectric Point: 6.3254

>AT287852 WP_006995246.1 NZ_LR134395:494664-494984 [Haemophilus aegyptius]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRIN
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References