287847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3390040..3391283 Replicon chromosome
Accession NZ_LR134388
Organism Legionella sainthelensi strain NCTC11988

Toxin (Protein)


Gene name HipT Uniprot ID A0A0W0YPA1
Locus tag EL220_RS14990 Protein ID WP_027272363.1
Coordinates 3390345..3391283 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0W0YPC6
Locus tag EL220_RS14985 Protein ID WP_027272362.1
Coordinates 3390040..3390348 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL220_RS18365 3385476..3386459 + 984 WP_197720967.1 Fic family protein -
EL220_RS14960 3386684..3387109 - 426 WP_027269472.1 helix-turn-helix domain-containing protein -
EL220_RS14965 3387112..3387399 - 288 WP_027269471.1 type II toxin-antitoxin system HigB family toxin -
EL220_RS14970 3387474..3388712 - 1239 WP_027269470.1 integrase family protein -
EL220_RS14975 3389093..3389644 - 552 Protein_2928 transposase -
EL220_RS14980 3389816..3390043 + 228 WP_027272361.1 helix-turn-helix transcriptional regulator -
EL220_RS14985 3390040..3390348 + 309 WP_027272362.1 HipA N-terminal domain-containing protein Antitoxin
EL220_RS14990 3390345..3391283 + 939 WP_027272363.1 HipA domain-containing protein Toxin
EL220_RS15000 3391447..3391740 + 294 WP_128130925.1 hypothetical protein -
EL220_RS15005 3391930..3392220 + 291 WP_027272365.1 hypothetical protein -
EL220_RS15010 3392294..3393643 - 1350 WP_027272366.1 DUF2130 domain-containing protein -
EL220_RS15015 3394051..3395784 - 1734 WP_027272367.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36048.86 Da        Isoelectric Point: 9.5712

>T287847 WP_027272363.1 NZ_LR134388:3390345-3391283 [Legionella sainthelensi]
MKRCPITYDVISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGGFEIVDQKG
QYILKPQSDIYPELPENEAITMTLAKAIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIQQFCTFPKIEFVKLFKLTLFNFLIGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAVEKLGLNQNIIDGIVQEFHQIIPEWRKLIGFSFLSQQMQEKYMELLDQRCKRFNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11579.50 Da        Isoelectric Point: 4.7863

>AT287847 WP_027272362.1 NZ_LR134388:3390040-3390348 [Legionella sainthelensi]
MRKACISVNGIRAGILEELEGKKYQFTYLNDYQGAPVSLTMPLTNKVYNFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0YPA1

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0YPC6

References