287829

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2852853..2854096 Replicon chromosome
Accession NZ_LR134374
Organism Legionella spiritensis strain NCTC12082

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag EL239_RS12675 Protein ID WP_126339573.1
Coordinates 2853158..2854096 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag EL239_RS12670 Protein ID WP_126339572.1
Coordinates 2852853..2853161 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL239_RS12650 2849237..2850850 - 1614 WP_126339570.1 HAMP domain-containing histidine kinase -
EL239_RS12655 2850847..2851533 - 687 WP_058484377.1 response regulator transcription factor -
EL239_RS12660 2851686..2852381 + 696 WP_126339571.1 hypothetical protein -
EL239_RS12665 2852629..2852856 + 228 WP_058484375.1 helix-turn-helix transcriptional regulator -
EL239_RS12670 2852853..2853161 + 309 WP_126339572.1 HipA N-terminal domain-containing protein Antitoxin
EL239_RS12675 2853158..2854096 + 939 WP_126339573.1 lpg2370 family Dot/Icm T4SS effector Toxin
EL239_RS12680 2854093..2854675 - 583 Protein_2492 tyrosine-type recombinase/integrase -
EL239_RS12685 2854758..2855666 + 909 WP_126339574.1 DMT family transporter -
EL239_RS15300 2855903..2856073 - 171 WP_172597098.1 SRPBCC domain-containing protein -
EL239_RS12695 2856243..2856626 - 384 WP_126339575.1 VOC family protein -
EL239_RS12700 2856814..2857494 - 681 WP_126339576.1 glutathione S-transferase family protein -
EL239_RS12710 2857943..2858230 - 288 WP_172597099.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(4-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35994.73 Da        Isoelectric Point: 9.3250

>T287829 WP_126339573.1 NZ_LR134374:2853158-2854096 [Legionella spiritensis]
MKRCPITYEKISNQENYSHRGLHLLSPQLKNLGPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKDGCFEIVDQNG
QYILKPQSDIYPELPENEAITMTLAKTISLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFFNYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGLSFLSQPMQEKYLQLLDQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.28 Da        Isoelectric Point: 4.5858

>AT287829 WP_126339572.1 NZ_LR134374:2852853-2853161 [Legionella spiritensis]
MRKACVSVNGVKAGTLEELQGGTYQFTYFDDYHGAPVSLTMPLTKKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLIIVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References