Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1785461..1786063 Replicon chromosome
Accession NZ_LR134365
Organism Cardiobacterium hominis strain NCTC10426

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL199_RS08700 Protein ID WP_081447840.1
Coordinates 1785461..1785739 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL199_RS08705 Protein ID WP_004142238.1
Coordinates 1785749..1786063 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL199_RS08680 1780902..1781552 - 651 WP_004142250.1 ABC transporter ATP-binding protein -
EL199_RS08685 1781557..1782687 - 1131 WP_004142249.1 ABC transporter permease -
EL199_RS08690 1782677..1783957 - 1281 WP_004142247.1 ABC transporter permease -
EL199_RS08695 1783962..1785353 - 1392 WP_004142244.1 DUF2318 domain-containing protein -
EL199_RS08700 1785461..1785739 + 279 WP_081447840.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL199_RS08705 1785749..1786063 + 315 WP_004142238.1 HigA family addiction module antidote protein Antitoxin
EL199_RS08710 1786115..1786864 - 750 WP_004142236.1 SDR family NAD(P)-dependent oxidoreductase -
EL199_RS08715 1786861..1787805 - 945 WP_126316058.1 biotin--[acetyl-CoA-carboxylase] ligase -
EL199_RS08720 1787844..1788116 - 273 WP_004142231.1 type II toxin-antitoxin system YafQ family toxin -
EL199_RS08725 1788109..1788408 - 300 WP_004142230.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
EL199_RS08730 1788567..1789862 + 1296 WP_004142227.1 NCS2 family permease -
EL199_RS08735 1789875..1790030 - 156 WP_197719326.1 ribosome alternative rescue factor ArfA -
EL199_RS08740 1790226..1790804 + 579 WP_040355599.1 electron transport complex subunit RsxA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(26-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10747.22 Da        Isoelectric Point: 8.3076

>T287818 WP_081447840.1 NZ_LR134365:1785461-1785739 [Cardiobacterium hominis]
MISNFSCKDTEALFRGRQVRRFIAIERIALRKLQQLHAASNLQFLRVPPGNRLEALQGNRAGQYSIHINDQWHICFCWED
GNANHVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11536.30 Da        Isoelectric Point: 6.4806

>AT287818 WP_004142238.1 NZ_LR134365:1785749-1786063 [Cardiobacterium hominis]
MTREIPLIHPGEILLEDWLKPLGISQTALAKAIAVPPRRIHEIIAGKRAISADTALRLAVFFQTDAQSWLNLQSHYDAEQ
TREKLAGTLAHIPAYDTLALSENI

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References