Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/DinJ(antitoxin) |
Location | 1687160..1687793 | Replicon | chromosome |
Accession | NZ_LR134354 | ||
Organism | Bifidobacterium longum subsp. infantis strain NCTC11817 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | W6EYF0 |
Locus tag | EL189_RS08390 | Protein ID | WP_012577854.1 |
Coordinates | 1687160..1687528 (-) | Length | 123 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | B7GS37 |
Locus tag | EL189_RS08395 | Protein ID | WP_012577855.1 |
Coordinates | 1687509..1687793 (-) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EL189_RS08345 | 1682790..1683047 | + | 258 | WP_012577847.1 | hypothetical protein | - |
EL189_RS08350 | 1683044..1683535 | + | 492 | WP_012577848.1 | hypothetical protein | - |
EL189_RS08355 | 1683681..1684085 | - | 405 | WP_014484963.1 | tyrosine-type recombinase/integrase | - |
EL189_RS08360 | 1684082..1684342 | - | 261 | WP_012577849.1 | hypothetical protein | - |
EL189_RS08365 | 1684497..1684841 | - | 345 | WP_012577850.1 | hypothetical protein | - |
EL189_RS08370 | 1684972..1685343 | - | 372 | WP_012577851.1 | hypothetical protein | - |
EL189_RS08375 | 1685450..1686205 | - | 756 | WP_012577852.1 | hypothetical protein | - |
EL189_RS08380 | 1686202..1686429 | - | 228 | WP_014484964.1 | hypothetical protein | - |
EL189_RS08385 | 1686426..1686971 | - | 546 | WP_012577853.1 | hypothetical protein | - |
EL189_RS08390 | 1687160..1687528 | - | 369 | WP_012577854.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
EL189_RS08395 | 1687509..1687793 | - | 285 | WP_012577855.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
EL189_RS08400 | 1687869..1688168 | - | 300 | WP_012577856.1 | hypothetical protein | - |
EL189_RS08405 | 1688256..1688438 | - | 183 | WP_014484966.1 | hypothetical protein | - |
EL189_RS08410 | 1688438..1688779 | - | 342 | WP_012577857.1 | hypothetical protein | - |
EL189_RS08415 | 1688781..1689566 | - | 786 | WP_012577858.1 | hypothetical protein | - |
EL189_RS08420 | 1689765..1690106 | - | 342 | WP_012577859.1 | hypothetical protein | - |
EL189_RS08425 | 1690220..1690564 | - | 345 | WP_014484967.1 | hypothetical protein | - |
EL189_RS13800 | 1690561..1690722 | - | 162 | WP_155245937.1 | hypothetical protein | - |
EL189_RS08430 | 1690812..1691426 | - | 615 | WP_012577862.1 | lysozyme | - |
EL189_RS08435 | 1691639..1691866 | - | 228 | WP_025221588.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 1660722..1723283 | 62561 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13866.75 Da Isoelectric Point: 4.5746
>T287798 WP_012577854.1 NZ_LR134354:c1687528-1687160 [Bifidobacterium longum subsp. infantis]
MTSTPSEPRLYDVWLMWVEFPDHPGIGKPRPVVITEVDGDLVSGIVAKITGNTDWDEAGDVPLLDWKAEGLLKPSLVRCS
QRFYFNRSELLQWFGRLSLRDAEHVNDGLEATLDIPPYRRSV
MTSTPSEPRLYDVWLMWVEFPDHPGIGKPRPVVITEVDGDLVSGIVAKITGNTDWDEAGDVPLLDWKAEGLLKPSLVRCS
QRFYFNRSELLQWFGRLSLRDAEHVNDGLEATLDIPPYRRSV
Download Length: 369 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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