Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2038164..2038752 Replicon chromosome
Accession NZ_LR134352
Organism Nocardia asteroides strain NCTC11293

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag EL493_RS09425 Protein ID WP_030200292.1
Coordinates 2038164..2038445 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL493_RS09430 Protein ID WP_019045366.1
Coordinates 2038459..2038752 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL493_RS09405 2034062..2035384 - 1323 WP_019045361.1 2-oxo acid dehydrogenase subunit E2 -
EL493_RS09410 2035400..2036374 - 975 WP_019045362.1 alpha-ketoacid dehydrogenase subunit beta -
EL493_RS09415 2036371..2037453 - 1083 WP_019045363.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
EL493_RS09420 2037624..2038115 + 492 WP_019045364.1 Lrp/AsnC family transcriptional regulator -
EL493_RS09425 2038164..2038445 + 282 WP_030200292.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL493_RS09430 2038459..2038752 + 294 WP_019045366.1 HigA family addiction module antidote protein Antitoxin
EL493_RS09435 2038894..2040513 + 1620 WP_019045367.1 restriction endonuclease -
EL493_RS09440 2040645..2040830 - 186 WP_030200277.1 hypothetical protein -
EL493_RS09445 2040841..2041176 + 336 WP_126405637.1 hypothetical protein -
EL493_RS09450 2041180..2042376 - 1197 WP_019045370.1 benzoate/H(+) symporter BenE family transporter -
EL493_RS09455 2042604..2043410 + 807 WP_197724382.1 sulfurtransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.43 Da        Isoelectric Point: 10.2158

>T287794 WP_030200292.1 NZ_LR134352:2038164-2038445 [Nocardia asteroides]
VIRSFGDRDTERLWHREHVKTFDSRILRVALRKLAILDAAVSLGELRVPPGNRLEALKGNRKGQYSLRINEQWRICFVWT
DAGPEQVAIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10807.56 Da        Isoelectric Point: 9.8274

>AT287794 WP_019045366.1 NZ_LR134352:2038459-2038752 [Nocardia asteroides]
MGKLAPVHPGEVLKEDFIEPLGITQHRVAVAIGVPPRRINEIVHGKRRITADTALRLGRYFGTSDIFWLNLQNRYDLEIE
RDAIGAALAAIQPLRVA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References