Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 220095..220792 Replicon chromosome
Accession NZ_LR134352
Organism Nocardia asteroides strain NCTC11293

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag EL493_RS01135 Protein ID WP_036835380.1
Coordinates 220095..220463 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL493_RS01140 Protein ID WP_019049601.1
Coordinates 220460..220792 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL493_RS01115 215346..216029 - 684 WP_019049596.1 type 1 glutamine amidotransferase domain-containing protein -
EL493_RS01120 216080..217660 - 1581 WP_019049597.1 succinate-semialdehyde dehydrogenase (NADP(+)) -
EL493_RS01125 217657..218586 - 930 WP_019049598.1 acetoacetate decarboxylase family protein -
EL493_RS01130 218762..220015 + 1254 WP_022566143.1 NADH:flavin oxidoreductase/NADH oxidase family protein -
EL493_RS01135 220095..220463 + 369 WP_036835380.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL493_RS01140 220460..220792 + 333 WP_019049601.1 helix-turn-helix domain-containing protein Antitoxin
EL493_RS01145 220850..221692 - 843 WP_019049602.1 hypothetical protein -
EL493_RS01150 221686..222396 - 711 WP_019049603.1 HAD-IB family hydrolase -
EL493_RS01155 222393..223169 - 777 WP_022566141.1 hypothetical protein -
EL493_RS01160 223445..223897 + 453 WP_019049605.1 SRPBCC family protein -
EL493_RS01165 223958..224398 - 441 WP_036835092.1 MarR family transcriptional regulator -
EL493_RS01170 224522..225484 + 963 WP_019049607.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-97)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13678.48 Da        Isoelectric Point: 4.9473

>T287791 WP_036835380.1 NZ_LR134352:220095-220463 [Nocardia asteroides]
VTWEIVLHPEVESWFLAICGTDPETGDLIERAIDHLASEGPSLGRPLVDRIKGSRYHNMKELRPASTGTTEVRILFAFDP
ARAAAMLVAGDKSNFWQGWYSEAIPLADKRFTEHLEALKEQS

Download         Length: 369 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12068.60 Da        Isoelectric Point: 8.6047

>AT287791 WP_019049601.1 NZ_LR134352:220460-220792 [Nocardia asteroides]
MSTEFSKWTDVKARARQQDPRSEAEQTAGALRADERHESYLRGHQLAEIRKAMGMTQVALAEALGVTQARVSKIERGEIS
GIDAIRAYVTALGGSVDVVVRLGDRTWNVA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References