287788

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2295531..2296048 Replicon chromosome
Accession NZ_LR134351
Organism Staphylococcus aureus strain NCTC13811

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag EL160_RS12265 Protein ID WP_000251928.1
Coordinates 2295531..2295797 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag EL160_RS12270 Protein ID WP_000584497.1
Coordinates 2295797..2296048 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL160_RS12240 2290739..2291275 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
EL160_RS12245 2291743..2292567 - 825 WP_000594640.1 formate/nitrite transporter family protein -
EL160_RS12250 2292770..2292952 - 183 WP_000079140.1 hypothetical protein -
EL160_RS12255 2293038..2293505 - 468 WP_000153340.1 SRPBCC domain-containing protein -
EL160_RS12260 2293691..2295238 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EL160_RS12265 2295531..2295797 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
EL160_RS12270 2295797..2296048 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL160_RS12275 2296212..2296312 - 101 Protein_2282 hypothetical protein -
EL160_RS12280 2296319..2296918 - 600 WP_000162804.1 DsbA family protein -
EL160_RS12285 2296937..2297299 - 363 WP_000819843.1 DUF4467 domain-containing protein -
EL160_RS12290 2297554..2298803 + 1250 Protein_2285 FemA/FemB family glycyltransferase FmhA -
EL160_RS12295 2298900..2299631 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
EL160_RS12300 2299628..2300347 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T287788 WP_000251928.1 NZ_LR134351:c2295797-2295531 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT287788 WP_000584497.1 NZ_LR134351:c2296048-2295797 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References