Detailed information of TA system TA287775

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1300979..1301558
• Replicon: chromosome
• Accession: NZ_LR134351
• Organism: Staphylococcus aureus strain NCTC13811

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: EL160_RS06610
• Protein ID: WP_001025401.1
• Coordinates: 1301313..1301558 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1300979..1301344 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL160_RS06570	1297722..1298279	-	558	WP_000645048.1	DUF2815 family protein	-
EL160_RS06575	1298305..1299471	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
EL160_RS06580	1299468..1299830	-	363	WP_129545264.1	hypothetical protein	-
EL160_RS06585	1299845..1300168	-	324	WP_000174998.1	hypothetical protein	-
EL160_RS06590	1300247..1300408	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
EL160_RS06595	1300421..1300684	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
EL160_RS06600	1300709..1300924	-	216	WP_001097552.1	hypothetical protein	-
EL160_RS06605	1300979..1301344	+	366	WP_001128433.1	hypothetical protein	Antitoxin
EL160_RS06610	1301313..1301558	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
EL160_RS06615	1301625..1302005	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
EL160_RS06620	1301992..1302189	-	198	WP_001148860.1	hypothetical protein	-
EL160_RS06625	1302259..1302471	+	213	WP_000362644.1	hypothetical protein	-
EL160_RS15480	1302512..1302661	-	150	WP_000771849.1	hypothetical protein	-
EL160_RS06630	1302676..1303119	-	444	WP_000435357.1	hypothetical protein	-
EL160_RS06635	1303167..1303379	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
EL160_RS06640	1303531..1304262	+	732	WP_000511090.1	XRE family transcriptional regulator	-
EL160_RS06645	1304332..1304514	+	183	WP_000705240.1	hypothetical protein	-
EL160_RS06650	1304551..1304697	+	147	WP_001795334.1	hypothetical protein	-
EL160_RS06655	1304694..1305308	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1261897..1324289	62392

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T287775 WP_001025401.1 NZ_LR134351:c1301558-1301313 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT287775 NZ_LR134351:1300979-1301344 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin