Detailed information of TA system TA287772

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 1264801..1265108
• Replicon: chromosome
• Accession: NZ_LR134351
• Organism: Staphylococcus aureus strain NCTC13811

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: EL160_RS06360
• Protein ID: WP_011447039.1
• Coordinates: 1264932..1265108 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1264801..1264940 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL160_RS06320	1259936..1260844	-	909	WP_000476878.1	DUF1672 domain-containing protein	-
EL160_RS06325	1260902..1261807	-	906	WP_000913238.1	DUF1672 domain-containing protein	-
EL160_RS06330	1261897..1262112	-	216	WP_000209712.1	hypothetical protein	-
EL160_RS06335	1262485..1263321	-	837	WP_000675478.1	hypothetical protein	-
EL160_RS06345	1263699..1264454	-	756	WP_000861038.1	CHAP domain-containing protein	-
EL160_RS06350	1264466..1264720	-	255	WP_000611512.1	phage holin	-
EL160_RS06355	1264772..1264879	+	108	WP_001791821.1	hypothetical protein	-
-	1264801..1264940	+	140	NuclAT_0	-	Antitoxin
-	1264801..1264940	+	140	NuclAT_0	-	Antitoxin
-	1264801..1264940	+	140	NuclAT_0	-	Antitoxin
-	1264801..1264940	+	140	NuclAT_0	-	Antitoxin
EL160_RS06360	1264932..1265108	-	177	WP_011447039.1	putative holin-like toxin	Toxin
EL160_RS06365	1265261..1265560	-	300	WP_000466784.1	DUF2951 domain-containing protein	-
EL160_RS06370	1265606..1265770	-	165	WP_000916020.1	XkdX family protein	-
EL160_RS06375	1265763..1266152	-	390	WP_001166599.1	DUF2977 domain-containing protein	-
EL160_RS06380	1266152..1267618	-	1467	WP_000067155.1	BppU family phage baseplate upper protein	-
EL160_RS06385	1267618..1269528	-	1911	WP_000429551.1	minor structural protein	-
EL160_RS06390	1269544..1269834	-	291	WP_000179860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1261897..1324289	62392

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T287772 WP_011447039.1 NZ_LR134351:c1265108-1264932 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT287772 NZ_LR134351:1264801-1264940 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin