Detailed information of TA system TA287770

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 11423..11730
• Replicon: chromosome
• Accession: NZ_LR134351
• Organism: Staphylococcus aureus strain NCTC13811

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: EL160_RS00050
• Protein ID: WP_011447039.1
• Coordinates: 11423..11599 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	11591..11730 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL160_RS00020	6697..6987	+	291	WP_000179860.1	hypothetical protein	-
EL160_RS00025	7003..8913	+	1911	WP_000429551.1	minor structural protein	-
EL160_RS00030	8913..10379	+	1467	WP_000067155.1	BppU family phage baseplate upper protein	-
EL160_RS00035	10379..10768	+	390	WP_001166599.1	DUF2977 domain-containing protein	-
EL160_RS00040	10761..10925	+	165	WP_000916020.1	XkdX family protein	-
EL160_RS00045	10971..11270	+	300	WP_000466784.1	DUF2951 domain-containing protein	-
EL160_RS00050	11423..11599	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	11591..11730	-	140	NuclAT_2	-	Antitoxin
-	11591..11730	-	140	NuclAT_2	-	Antitoxin
-	11591..11730	-	140	NuclAT_2	-	Antitoxin
-	11591..11730	-	140	NuclAT_2	-	Antitoxin
EL160_RS00055	11652..11759	-	108	WP_001791821.1	hypothetical protein	-
EL160_RS00060	11811..12065	+	255	WP_000611512.1	phage holin	-
EL160_RS00065	12077..12832	+	756	WP_000861038.1	CHAP domain-containing protein	-
EL160_RS00075	13685..14512	-	828	WP_000136022.1	alpha/beta hydrolase	-
EL160_RS00080	14570..15784	-	1215	WP_000286469.1	NADH-dependent flavin oxidoreductase	-
EL160_RS00085	15880..15978	+	99	WP_001803958.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	319..17093	16774

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T287770 WP_011447039.1 NZ_LR134351:11423-11599 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT287770 NZ_LR134351:c11730-11591 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin