Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1944962..1945557 Replicon chromosome
Accession NZ_LR134342
Organism Pseudomonas aeruginosa strain NCTC10728

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag EL327_RS09495 Protein ID WP_003113526.1
Coordinates 1945279..1945557 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL327_RS09490 Protein ID WP_003113527.1
Coordinates 1944962..1945267 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL327_RS09460 1940490..1940780 - 291 WP_126438354.1 DUF5447 family protein -
EL327_RS09465 1940784..1940999 - 216 WP_042911940.1 hypothetical protein -
EL327_RS09470 1940992..1941264 - 273 WP_025324668.1 hypothetical protein -
EL327_RS09480 1941715..1942047 + 333 WP_079282649.1 hypothetical protein -
EL327_RS09485 1942182..1944653 + 2472 WP_126438355.1 SIR2 family protein -
EL327_RS09490 1944962..1945267 - 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
EL327_RS09495 1945279..1945557 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL327_RS09505 1945886..1948114 + 2229 WP_003113525.1 TonB-dependent receptor -
EL327_RS09510 1948184..1948831 - 648 WP_003095021.1 carbonate dehydratase -
EL327_RS09515 1948893..1950131 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T287762 WP_003113526.1 NZ_LR134342:c1945557-1945279 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT287762 WP_003113527.1 NZ_LR134342:c1945267-1944962 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References