Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1320368..1321049 Replicon chromosome
Accession NZ_LR134342
Organism Pseudomonas aeruginosa strain NCTC10728

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL327_RS06580 Protein ID WP_015503432.1
Coordinates 1320684..1321049 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL327_RS06575 Protein ID WP_016561576.1
Coordinates 1320368..1320691 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL327_RS06535 1316261..1316944 - 684 WP_003120766.1 TetR/AcrR family transcriptional regulator -
EL327_RS06540 1317032..1317910 + 879 WP_003163191.1 hypothetical protein -
EL327_RS06550 1318513..1318740 + 228 WP_014603215.1 hypothetical protein -
EL327_RS06555 1318755..1319297 - 543 WP_019396018.1 tyrosine-type recombinase/integrase -
EL327_RS06560 1319472..1319747 - 276 WP_004353146.1 hypothetical protein -
EL327_RS06565 1319747..1320078 - 332 Protein_1269 hypothetical protein -
EL327_RS06570 1320133..1320252 + 120 Protein_1270 IS5/IS1182 family transposase -
EL327_RS06575 1320368..1320691 - 324 WP_016561576.1 XRE family transcriptional regulator Antitoxin
EL327_RS06580 1320684..1321049 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL327_RS06585 1321313..1321555 - 243 WP_043884955.1 hypothetical protein -
EL327_RS06590 1321762..1322034 + 273 WP_003085667.1 hypothetical protein -
EL327_RS06595 1322053..1322478 - 426 WP_034024285.1 VOC family protein -
EL327_RS06600 1322579..1323463 + 885 WP_003454589.1 LysR family transcriptional regulator -
EL327_RS06605 1323436..1324389 - 954 WP_003085661.1 LysR family transcriptional regulator -
EL327_RS06610 1324610..1325044 + 435 WP_016253806.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T287761 WP_015503432.1 NZ_LR134342:c1321049-1320684 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11903.72 Da        Isoelectric Point: 5.8900

>AT287761 WP_016561576.1 NZ_LR134342:c1320691-1320368 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQSRGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References