Detailed information of TA system TA287754

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2332129..2332354
• Replicon: chromosome
• Accession: NZ_LR134340
• Organism: Escherichia marmotae strain NCTC11133

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: EL192_RS11170
• Protein ID: WP_000813254.1
• Coordinates: 2332129..2332284 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2332296..2332354 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL192_RS11130	2327252..2327749	-	498	WP_001135310.1	lysozyme RrrD	-
EL192_RS11135	2327749..2327964	-	216	WP_000839565.1	phage lysis protein EssD	-
EL192_RS11140	2328216..2328590	-	375	WP_001348108.1	hypothetical protein	-
EL192_RS11145	2328762..2329190	-	429	WP_000506936.1	cell envelope integrity protein TolA	-
EL192_RS11150	2330235..2330777	-	543	WP_000640161.1	DUF1133 family protein	-
EL192_RS11155	2330774..2331064	-	291	WP_000247763.1	DUF1364 domain-containing protein	-
EL192_RS11160	2331064..2331663	-	600	WP_000940319.1	DUF1367 family protein	-
EL192_RS11170	2332129..2332284	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2332296..2332354	+	59	-	-	Antitoxin
EL192_RS11185	2332861..2333769	+	909	WP_001297700.1	bacteriophage abortive infection AbiH family protein	-
EL192_RS11190	2333859..2335250	+	1392	WP_000982358.1	hypothetical protein	-
EL192_RS11195	2335513..2335935	-	423	WP_016247241.1	DUF977 family protein	-
EL192_RS11200	2335976..2337046	-	1071	WP_001262357.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2298977..2346036	47059

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T287754 WP_000813254.1 NZ_LR134340:c2332284-2332129 [Escherichia marmotae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT287754 NZ_LR134340:2332296-2332354 [Escherichia marmotae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin