Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1238693..1239282 Replicon chromosome
Accession NZ_LR134339
Organism Corynebacterium minutissimum strain NCTC10285

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag EL179_RS05845 Protein ID WP_082013920.1
Coordinates 1238693..1238974 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL179_RS05850 Protein ID WP_039674786.1
Coordinates 1238983..1239282 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL179_RS05825 1234213..1235187 - 975 WP_039674779.1 selenide, water dikinase SelD -
EL179_RS05835 1235339..1236625 + 1287 WP_039674781.1 L-seryl-tRNA(Sec) selenium transferase -
EL179_RS05840 1236626..1238392 + 1767 WP_039674782.1 selenocysteine-specific translation elongation factor -
EL179_RS05845 1238693..1238974 + 282 WP_082013920.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL179_RS05850 1238983..1239282 + 300 WP_039674786.1 HigA family addiction module antidote protein Antitoxin
EL179_RS05855 1239292..1239546 - 255 WP_039674787.1 hypothetical protein -
EL179_RS05860 1239795..1240613 - 819 WP_039674788.1 hypothetical protein -
EL179_RS05865 1240739..1241536 + 798 WP_039674792.1 zinc transporter ZupT -
EL179_RS05870 1241540..1242460 - 921 WP_039674794.1 DUF808 domain-containing protein -
EL179_RS05875 1242505..1243041 - 537 WP_039674795.1 DUF402 domain-containing protein -
EL179_RS05880 1243041..1243763 - 723 WP_039674796.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(18-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10797.29 Da        Isoelectric Point: 10.8344

>T287744 WP_082013920.1 NZ_LR134339:1238693-1238974 [Corynebacterium minutissimum]
MIQSFANRDTELVWLRQASPRIDSRIHKTANRKLHQLDAAVSLQSLRVPPGNRLEALKGDRKGMYSIRVNQQWRITFRWT
EAGPADVAIEDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11085.78 Da        Isoelectric Point: 6.2247

>AT287744 WP_039674786.1 NZ_LR134339:1238983-1239282 [Corynebacterium minutissimum]
MSTKLYPPIHPGEVLNEDFIKAFGITQHKLAMAIGVPPRRINEIVHGKRGITADTALRLGRYFGVEPQFWVNLQGRYELE
IAEDSIAEEVSSIKPLEVA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References