Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 395818..396330 Replicon chromosome
Accession NZ_LR134336
Organism Streptococcus oralis ATCC 35037 strain NCTC 11427

Toxin (Protein)


Gene name yoeB Uniprot ID D4FRF2
Locus tag EL140_RS01985 Protein ID WP_000924723.1
Coordinates 396076..396330 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag EL140_RS01980 Protein ID WP_004181012.1
Coordinates 395818..396072 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL140_RS01945 391579..391890 + 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -
EL140_RS01950 391941..392570 + 630 WP_000963719.1 nicotinate-nucleotide adenylyltransferase -
EL140_RS01955 392570..393163 + 594 WP_000331233.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EL140_RS01960 393164..393517 + 354 WP_001003013.1 ribosome silencing factor -
EL140_RS01970 393832..394578 + 747 WP_078232917.1 class I SAM-dependent methyltransferase -
EL140_RS01975 394588..395685 + 1098 WP_000156374.1 nucleotidyltransferase -
EL140_RS01980 395818..396072 + 255 WP_004181012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL140_RS01985 396076..396330 + 255 WP_000924723.1 Txe/YoeB family addiction module toxin Toxin
EL140_RS01990 396534..398147 + 1614 WP_000404956.1 ribonuclease Y -
EL140_RS01995 398282..398908 + 627 WP_000775041.1 guanylate kinase -
EL140_RS02000 398933..399247 + 315 WP_002874282.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10113.58 Da        Isoelectric Point: 7.9716

>T287739 WP_000924723.1 NZ_LR134336:396076-396330 [Streptococcus oralis ATCC 35037]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFVGMGKPEPLKYDYQGAWSRRIDAENRLIYMIDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9734.05 Da        Isoelectric Point: 4.8430

>AT287739 WP_004181012.1 NZ_LR134336:395818-396072 [Streptococcus oralis ATCC 35037]
MEVVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X0WZT2

Antitoxin

Source ID Structure

References