28771

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2975824..2976472 Replicon chromosome
Accession NC_020089
Organism Mycobacterium tuberculosis 7199-99

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag MT7199_RS13950 Protein ID WP_003899414.1
Coordinates 2975824..2976147 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag MT7199_RS13955 Protein ID WP_003899415.1
Coordinates 2976227..2976472 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT7199_RS13920 2971147..2972145 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
MT7199_RS13925 2972159..2972623 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
MT7199_RS13930 2972611..2972862 + 252 WP_003908028.1 hypothetical protein -
MT7199_RS13935 2973033..2974472 - 1440 WP_003899411.1 phage major capsid protein -
MT7199_RS13940 2974480..2975013 - 534 WP_003899412.1 HK97 family phage prohead protease -
MT7199_RS21555 2975166..2975657 - 492 WP_003900541.1 phage terminase small subunit P27 family -
MT7199_RS13950 2975824..2976147 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
MT7199_RS13955 2976227..2976472 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
MT7199_RS13960 2976469..2977896 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
MT7199_RS13965 2977898..2978290 - 393 WP_003899417.1 DUF2742 domain-containing protein -
MT7199_RS13970 2978287..2978547 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
MT7199_RS13975 2978564..2978926 - 363 WP_003900543.1 hypothetical protein -
MT7199_RS13980 2978929..2980056 - 1128 WP_003899420.1 site-specific integrase -
MT7199_RS13985 2980201..2980428 - 228 WP_003899421.1 hypothetical protein -
MT7199_RS21560 2980425..2980814 - 390 WP_003899422.1 hypothetical protein -
MT7199_RS13990 2980720..2980992 + 273 WP_003900544.1 hypothetical protein -
MT7199_RS13995 2981091..2981324 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2971147..2980056 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T28771 WP_003899414.1 NC_020089:c2976147-2975824 [Mycobacterium tuberculosis 7199-99]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T28771 NC_020089:c2976147-2975824 [Mycobacterium tuberculosis 7199-99]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT28771 WP_003899415.1 NC_020089:c2976472-2976227 [Mycobacterium tuberculosis 7199-99]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT28771 NC_020089:c2976472-2976227 [Mycobacterium tuberculosis 7199-99]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References