287708

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2720089..2721332 Replicon chromosome
Accession NZ_LR134332
Organism Legionella pneumophila strain NCTC11193

Toxin (Protein)


Gene name HipT Uniprot ID Q5ZSZ6
Locus tag EL176_RS12350 Protein ID WP_010948074.1
Coordinates 2720394..2721332 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q5ZSZ7
Locus tag EL176_RS12345 Protein ID WP_010948073.1
Coordinates 2720089..2720397 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL176_RS12320 2715525..2715890 + 366 WP_010948069.1 BRCT domain-containing protein -
EL176_RS12325 2716247..2716612 - 366 WP_010948070.1 TraK family protein -
EL176_RS15790 2716797..2716937 - 141 WP_153802426.1 hypothetical protein -
EL176_RS12330 2716940..2718691 - 1752 WP_010948071.1 DUF927 domain-containing protein -
EL176_RS12335 2718757..2719032 - 276 WP_010948072.1 helix-turn-helix domain-containing protein -
EL176_RS12340 2719865..2720092 + 228 WP_006870829.1 helix-turn-helix transcriptional regulator -
EL176_RS12345 2720089..2720397 + 309 WP_010948073.1 HipA N-terminal domain-containing protein Antitoxin
EL176_RS12350 2720394..2721332 + 939 WP_010948074.1 lpg2370 family Dot/Icm T4SS effector Toxin
EL176_RS12360 2721875..2722489 + 615 WP_010948075.1 hypothetical protein -
EL176_RS12365 2722645..2722851 - 207 WP_015444115.1 hypothetical protein -
EL176_RS12370 2723188..2724456 + 1269 WP_010948076.1 lpg2372 family Dot/Icm T4SS effector -
EL176_RS12375 2724672..2725197 - 526 Protein_2379 hypothetical protein -
EL176_RS12380 2725197..2725862 - 666 WP_015444114.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36077.81 Da        Isoelectric Point: 8.6882

>T287708 WP_010948074.1 NZ_LR134332:2720394-2721332 [Legionella pneumophila]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11557.38 Da        Isoelectric Point: 4.5994

>AT287708 WP_010948073.1 NZ_LR134332:2720089-2720397 [Legionella pneumophila]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VKC
PDB 7VKB
PDB 7WCF

Antitoxin

Source ID Structure
PDB 7VKB
AlphaFold DB Q5ZSZ7

References