Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2782404..2782926 Replicon chromosome
Accession NZ_LR134331
Organism Lacticaseibacillus rhamnosus strain NCTC13764

Toxin (Protein)


Gene name yoeB Uniprot ID C2JUK2
Locus tag EL173_RS14055 Protein ID WP_005687756.1
Coordinates 2782666..2782926 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C2JUK3
Locus tag EL173_RS14050 Protein ID WP_005687754.1
Coordinates 2782404..2782673 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL173_RS14035 2777891..2779759 - 1869 WP_014571687.1 HTH domain-containing protein -
EL173_RS14040 2779786..2780586 - 801 WP_005690776.1 SDR family oxidoreductase -
EL173_RS14045 2781192..2782208 - 1017 WP_019728331.1 IS30 family transposase -
EL173_RS14050 2782404..2782673 + 270 WP_005687754.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EL173_RS14055 2782666..2782926 + 261 WP_005687756.1 Txe/YoeB family addiction module toxin Toxin
EL173_RS14060 2783137..2783865 - 729 WP_014571689.1 L-ribulose-5-phosphate 4-epimerase -
EL173_RS14065 2784062..2784883 + 822 WP_005690770.1 Cof-type HAD-IIB family hydrolase -
EL173_RS14070 2784950..2785837 - 888 WP_014571690.1 L-ribulose-5-phosphate 3-epimerase -
EL173_RS14075 2786022..2786801 - 780 WP_005690765.1 DeoR/GlpR family DNA-binding transcription regulator -
EL173_RS14080 2786869..2787510 - 642 WP_005690763.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10485.91 Da        Isoelectric Point: 9.6577

>T287707 WP_005687756.1 NZ_LR134331:2782666-2782926 [Lacticaseibacillus rhamnosus]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS

Download         Length: 261 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10181.39 Da        Isoelectric Point: 4.6755

>AT287707 WP_005687754.1 NZ_LR134331:2782404-2782673 [Lacticaseibacillus rhamnosus]
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249N526

Antitoxin

Source ID Structure
AlphaFold DB A0A249N594

References