Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 717423..718018 Replicon chromosome
Accession NZ_LR134330
Organism Pseudomonas aeruginosa strain NCTC13715

Toxin (Protein)


Gene name higB Uniprot ID A0A9E8L6K5
Locus tag EL342_RS03420 Protein ID WP_071534386.1
Coordinates 717740..718018 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL342_RS03415 Protein ID WP_003133769.1
Coordinates 717423..717728 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL342_RS03380 712564..713412 + 849 WP_009878189.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
EL342_RS03390 713579..714520 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
EL342_RS03395 714637..715251 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
EL342_RS03400 715293..715877 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
EL342_RS03405 715918..717018 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
EL342_RS03415 717423..717728 - 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
EL342_RS03420 717740..718018 - 279 WP_071534386.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL342_RS03430 718341..720569 + 2229 WP_033938414.1 TonB-dependent receptor -
EL342_RS03435 720639..721286 - 648 WP_003095021.1 carbonate dehydratase -
EL342_RS03440 721348..722586 - 1239 WP_033938412.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10698.23 Da        Isoelectric Point: 7.9184

>T287698 WP_071534386.1 NZ_LR134330:c718018-717740 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMHHAATELRDLRSPPGNRLEPLQGKRVGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT287698 WP_003133769.1 NZ_LR134330:c717728-717423 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References