Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4001963..4002576 Replicon chromosome
Accession NZ_LR134329
Organism Bordetella parapertussis strain NCTC10524

Toxin (Protein)


Gene name higB Uniprot ID K0MEM3
Locus tag EL261_RS19050 Protein ID WP_003811545.1
Coordinates 4001963..4002274 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL261_RS19055 Protein ID WP_003811547.1
Coordinates 4002277..4002576 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL261_RS19025 3997115..3997669 - 555 Protein_3726 LamB/YcsF family protein -
EL261_RS19030 3997666..3999060 - 1395 WP_003811536.1 arylsulfatase -
EL261_RS19035 3999075..4000037 - 963 WP_041937418.1 tripartite tricarboxylate transporter substrate binding protein -
EL261_RS19040 4000154..4001107 + 954 WP_041937234.1 LysR family transcriptional regulator -
EL261_RS19045 4001226..4001849 + 624 WP_003811542.1 glutathione S-transferase family protein -
EL261_RS19050 4001963..4002274 + 312 WP_003811545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL261_RS19055 4002277..4002576 + 300 WP_003811547.1 helix-turn-helix domain-containing protein Antitoxin
EL261_RS19060 4002590..4005181 - 2592 WP_065956700.1 autotransporter domain-containing protein -
EL261_RS19065 4005311..4005985 + 675 WP_010928712.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11810.72 Da        Isoelectric Point: 8.8245

>T287696 WP_003811545.1 NZ_LR134329:4001963-4002274 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Download         Length: 312 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10946.70 Da        Isoelectric Point: 11.2467

>AT287696 WP_003811547.1 NZ_LR134329:4002277-4002576 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0MEM3

Antitoxin

Source ID Structure

References