Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3666711..3667411 Replicon chromosome
Accession NZ_LR134326
Organism Bordetella bronchiseptica strain NCTC10543

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0H3LPJ8
Locus tag EL288_RS17085 Protein ID WP_003809515.1
Coordinates 3667115..3667411 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag EL288_RS17080 Protein ID WP_003809516.1
Coordinates 3666711..3667112 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL288_RS17050 3661896..3662918 - 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -
EL288_RS17055 3663055..3664092 - 1038 WP_003809529.1 threonylcarbamoyl-AMP synthase -
EL288_RS17060 3664112..3665302 - 1191 WP_003809527.1 5-(carboxyamino)imidazole ribonucleotide synthase -
EL288_RS17065 3665305..3665820 - 516 WP_033454360.1 5-(carboxyamino)imidazole ribonucleotide mutase -
EL288_RS17070 3665968..3666447 - 480 WP_003809523.1 disulfide bond formation protein B -
EL288_RS17075 3666455..3666691 - 237 WP_003809519.1 hypothetical protein -
EL288_RS17080 3666711..3667112 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EL288_RS17085 3667115..3667411 - 297 WP_003809515.1 type II toxin-antitoxin system MqsR family toxin Toxin
EL288_RS17090 3667694..3668575 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EL288_RS17095 3668801..3669247 + 447 WP_003809511.1 GFA family protein -
EL288_RS17100 3669333..3670397 - 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
EL288_RS17105 3670573..3671115 - 543 WP_003809508.1 MOSC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10608.50 Da        Isoelectric Point: 7.9291

>T287690 WP_003809515.1 NZ_LR134326:c3667411-3667115 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Download         Length: 297 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT287690 WP_003809516.1 NZ_LR134326:c3667112-3666711 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3LPJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References