Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2524384..2524997 Replicon chromosome
Accession NZ_LR134326
Organism Bordetella bronchiseptica strain NCTC10543

Toxin (Protein)


Gene name higB Uniprot ID K0MEM3
Locus tag EL288_RS11790 Protein ID WP_003811545.1
Coordinates 2524686..2524997 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL288_RS11785 Protein ID WP_003811547.1
Coordinates 2524384..2524683 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL288_RS11775 2520492..2521166 - 675 WP_003811550.1 response regulator transcription factor -
EL288_RS11780 2521296..2524370 + 3075 WP_126621938.1 autotransporter SphB2 -
EL288_RS11785 2524384..2524683 - 300 WP_003811547.1 helix-turn-helix domain-containing protein Antitoxin
EL288_RS11790 2524686..2524997 - 312 WP_003811545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL288_RS11795 2525111..2525734 - 624 WP_003811542.1 glutathione S-transferase family protein -
EL288_RS11800 2525853..2526806 - 954 WP_033451213.1 LysR family transcriptional regulator -
EL288_RS11805 2526924..2527886 + 963 WP_003811538.1 tripartite tricarboxylate transporter substrate binding protein -
EL288_RS11810 2527901..2529295 + 1395 WP_003811536.1 arylsulfatase -
EL288_RS11815 2529292..2529879 + 588 WP_003811534.1 LamB/YcsF family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11810.72 Da        Isoelectric Point: 8.8245

>T287689 WP_003811545.1 NZ_LR134326:c2524997-2524686 [Bordetella bronchiseptica]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Download         Length: 312 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10946.70 Da        Isoelectric Point: 11.2467

>AT287689 WP_003811547.1 NZ_LR134326:c2524683-2524384 [Bordetella bronchiseptica]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0MEM3

Antitoxin

Source ID Structure

References