Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1820748..1821261 Replicon chromosome
Accession NZ_LR134323
Organism Streptococcus urinalis strain NCTC13766

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag EL133_RS09360 Protein ID WP_000481712.1
Coordinates 1820748..1821002 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag EL133_RS09365 Protein ID WP_000387490.1
Coordinates 1820995..1821261 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL133_RS09340 1816517..1819018 - 2502 WP_006740462.1 ATP-binding protein -
EL133_RS09345 1819039..1819449 - 411 WP_000390748.1 conjugal transfer protein -
EL133_RS09350 1819453..1819721 - 269 Protein_1835 hypothetical protein -
EL133_RS09355 1819742..1820695 - 954 WP_006738423.1 conjugal transfer protein -
EL133_RS09360 1820748..1821002 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
EL133_RS09365 1820995..1821261 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EL133_RS09370 1821406..1821879 - 474 WP_000560386.1 hypothetical protein -
EL133_RS09375 1821887..1822369 - 483 WP_000383282.1 antirestriction protein ArdA -
EL133_RS09380 1822421..1822693 - 273 WP_006738396.1 hypothetical protein -
EL133_RS09385 1822825..1823178 - 354 WP_000571928.1 helix-turn-helix domain-containing protein -
EL133_RS09390 1823171..1823377 - 207 WP_196792585.1 helix-turn-helix domain-containing protein -
EL133_RS09395 1823370..1823747 - 378 WP_000287184.1 hypothetical protein -
EL133_RS09400 1823763..1824995 - 1233 WP_006738730.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1808071..1837882 29811


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T287684 WP_000481712.1 NZ_LR134323:c1821002-1820748 [Streptococcus urinalis]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT287684 WP_000387490.1 NZ_LR134323:c1821261-1820995 [Streptococcus urinalis]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References