Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4437612..4438214 Replicon chromosome
Accession NZ_LR134315
Organism Escherichia coli strain NCTC9064

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag EL184_RS21575 Protein ID WP_000897305.1
Coordinates 4437903..4438214 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL184_RS21570 Protein ID WP_000356397.1
Coordinates 4437612..4437902 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL184_RS21545 4433557..4434459 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
EL184_RS21550 4434456..4435091 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
EL184_RS21555 4435088..4436017 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
EL184_RS21560 4436347..4436589 - 243 WP_001086388.1 hypothetical protein -
EL184_RS21565 4436808..4437026 - 219 WP_001295676.1 ribbon-helix-helix domain-containing protein -
EL184_RS21570 4437612..4437902 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
EL184_RS21575 4437903..4438214 - 312 WP_000897305.1 hypothetical protein Toxin
EL184_RS21580 4438443..4439351 + 909 WP_044722469.1 alpha/beta hydrolase -
EL184_RS21585 4439519..4441333 - 1815 WP_096835633.1 hypothetical protein -
EL184_RS21590 4441748..4442689 - 942 WP_157912355.1 fatty acid biosynthesis protein FabY -
EL184_RS21595 4442734..4443171 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T287656 WP_000897305.1 NZ_LR134315:c4438214-4437903 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT287656 WP_000356397.1 NZ_LR134315:c4437902-4437612 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References