Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3571858..3572399 Replicon chromosome
Accession NZ_LR134315
Organism Escherichia coli strain NCTC9064

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag EL184_RS17470 Protein ID WP_000615976.1
Coordinates 3572121..3572399 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag EL184_RS17465 Protein ID WP_000729704.1
Coordinates 3571858..3572118 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL184_RS17440 3567641..3568426 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
EL184_RS17445 3568398..3570110 + 1713 Protein_3374 flagellar biosynthesis protein FlhA -
EL184_RS17450 3570215..3570493 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
EL184_RS17455 3570486..3570842 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
EL184_RS17460 3570899..3571672 - 774 WP_122997382.1 C40 family peptidase -
EL184_RS17465 3571858..3572118 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EL184_RS17470 3572121..3572399 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EL184_RS17475 3572555..3573295 + 741 WP_001225679.1 murein L,D-transpeptidase -
EL184_RS17480 3573266..3574033 - 768 WP_000333380.1 class II glutamine amidotransferase -
EL184_RS17485 3574239..3574817 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T287652 WP_000615976.1 NZ_LR134315:3572121-3572399 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT287652 WP_000729704.1 NZ_LR134315:3571858-3572118 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References