Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1766705..1767207 Replicon chromosome
Accession NZ_LR134315
Organism Escherichia coli strain NCTC9064

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL184_RS08515 Protein ID WP_000767829.1
Coordinates 1766953..1767207 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL184_RS08510 Protein ID WP_001259255.1
Coordinates 1766705..1766956 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL184_RS08485 1761883..1762950 - 1068 WP_096835714.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL184_RS08490 1762950..1764020 - 1071 WP_096835715.1 histidinol-phosphate transaminase -
EL184_RS08495 1764017..1765321 - 1305 WP_096835716.1 histidinol dehydrogenase -
EL184_RS08500 1765327..1766226 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL184_RS08505 1766372..1766422 - 51 WP_001364200.1 his operon leader peptide -
EL184_RS08510 1766705..1766956 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL184_RS08515 1766953..1767207 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL184_RS08520 1767290..1768114 + 825 WP_096835717.1 SDR family oxidoreductase -
EL184_RS08525 1768160..1769089 + 930 WP_000803360.1 LysR family transcriptional regulator -
EL184_RS08530 1769304..1769366 + 63 WP_010723108.1 membrane protein YoeI -
EL184_RS08535 1769356..1770714 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL184_RS08540 1770893..1771951 + 1059 WP_000492340.1 transport protein YeeE -
EL184_RS08545 1771965..1772192 + 228 WP_096835718.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287642 WP_000767829.1 NZ_LR134315:1766953-1767207 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287642 WP_001259255.1 NZ_LR134315:1766705-1766956 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References