Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 588285..589084 Replicon chromosome
Accession NZ_LR134315
Organism Escherichia coli strain NCTC9064

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag EL184_RS02895 Protein ID WP_000347273.1
Coordinates 588285..588749 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag EL184_RS02900 Protein ID WP_001307405.1
Coordinates 588749..589084 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL184_RS02865 583286..583720 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
EL184_RS02870 583738..584616 - 879 WP_096835512.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EL184_RS02875 584606..585385 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EL184_RS02880 585396..585869 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
EL184_RS02885 585892..587172 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
EL184_RS02890 587421..588230 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
EL184_RS02895 588285..588749 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EL184_RS02900 588749..589084 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EL184_RS02905 589233..590804 - 1572 WP_001273771.1 galactarate dehydratase -
EL184_RS02910 591179..592513 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
EL184_RS02915 592529..593299 + 771 WP_001058220.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 588285..599836 11551


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T287635 WP_000347273.1 NZ_LR134315:c588749-588285 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT287635 WP_001307405.1 NZ_LR134315:c589084-588749 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References