Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 500250..500831 Replicon chromosome
Accession NZ_LR134313
Organism Neisseria canis strain NCTC10296

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL143_RS02405 Protein ID WP_085417570.1
Coordinates 500553..500831 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL143_RS02400 Protein ID WP_085417571.1
Coordinates 500250..500543 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL143_RS02365 495728..496276 - 549 WP_085416868.1 oligoribonuclease -
EL143_RS02375 496605..497249 - 645 Protein_461 site-specific integrase -
EL143_RS02380 497417..497746 - 330 WP_085416870.1 helix-turn-helix domain-containing protein -
EL143_RS02385 497969..498636 + 668 Protein_463 IS1595 family transposase -
EL143_RS02390 499151..499801 - 651 WP_085417572.1 helix-turn-helix domain-containing protein -
EL143_RS02395 499916..500101 + 186 WP_085417573.1 helix-turn-helix domain-containing protein -
EL143_RS02400 500250..500543 - 294 WP_085417571.1 HigA family addiction module antidote protein Antitoxin
EL143_RS02405 500553..500831 - 279 WP_085417570.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL143_RS02410 500874..501059 + 186 WP_085417569.1 hypothetical protein -
EL143_RS02415 501076..501534 + 459 WP_085417568.1 hypothetical protein -
EL143_RS02420 501699..502676 + 978 WP_085417567.1 IS30 family transposase -
EL143_RS02425 502664..503398 + 735 WP_085417566.1 N-6 DNA methylase -
EL143_RS02430 503421..503672 + 252 WP_085417565.1 hypothetical protein -
EL143_RS02435 503684..503878 + 195 WP_126326515.1 hypothetical protein -
EL143_RS02440 503869..504408 + 540 Protein_474 hypothetical protein -
EL143_RS02445 504705..505034 - 330 Protein_475 zeta-toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 497969..502676 4707


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10832.42 Da        Isoelectric Point: 9.8031

>T287630 WP_085417570.1 NZ_LR134313:c500831-500553 [Neisseria canis]
MIQTFNCKHTEQLFQGRCPLKFRAIRKTAERKLQMLDSAVTVDFLRSPPGNRLEALKGSRTGQFSIRINDQWRVCFRFEN
GHAYDVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10926.58 Da        Isoelectric Point: 6.7234

>AT287630 WP_085417571.1 NZ_LR134313:c500543-500250 [Neisseria canis]
MNNQMRPIHPGEILREEYLIPLGITANALSVALHVPAPRINDIVREKRGISPDTALRLARYFGGDAQSWLNLQNAYDLKV
AEQSLKQEIDHIIPMQA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References